Research Paper
Cancer Epidemiology Biomarkers & Prevention: Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers
May 11, 2012
Amanda B Spurdle 1, Louise Marquart, Lesley McGuffog, Sue Healey, Olga Sinilnikova, Fei Wan, Xiaoqing Chen, Jonathan Beesley, Christian F Singer, Anne-Catharine Dressler, Daphne Gschwantler-Kaulich, Joanne L Blum, Nadine Tung, Jeff Weitzel, Henry Lynch, Judy Garber, Douglas F Easton, Susan Peock, Margaret Cook, Clare T Oliver, Debra Frost, Don Conroy, D Gareth Evans, Fiona Lalloo, Ros Eeles, Louise Izatt, Rosemarie Davidson, Carol Chu, Diana Eccles, Christina G Selkirk, Mary Daly, Claudine Isaacs, Dominique Stoppa-Lyonnet, Olga M Sinilnikova, Bruno Buecher, Muriel Belotti, Sylvie Mazoyer, Laure Barjhoux, Carole Verny-Pierre, Christine Lasset, Hélène Dreyfus, Pascal Pujol, Marie-Agnès Collonge-Rame, GEMO Study Collaborators; Matti A […]
Science: Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress
April 13, 2012
In Hye Lee1, Yoshichika Kawai1, Maria M. Fergusson1, Ilsa I. Rovira1, Alexander J. R. Bishop2, Noboru Motoyama3, Liu Cao4,*, Toren Finkel1,* Starvation and Autophagy Starvation stimulates withdrawal from the cell cycle, as well as stimulating autophagy. Are these two events connected? Lee et al. (p. 225) show a direct and nutrient-sensitive interaction between the tumor suppressor p53 and the essential autophagy gene […]
PNAS: Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation
April 10, 2012
Yao-Fu Chang, Jennifer S. Lee-Chang, J. Saadi Imam, Kalyan Chakravarthy Buddavarapu, Sarah S. Subaran, Amiya P. Sinha-Hikim, Myriam Gorospe, and Manjeet K. Rao Abstract Decoupling of transcription and translation during postmeiotic germ cell differentiation is critical for successful spermatogenesis. Here we establish that the interaction between microRNAs and actin-associated protein Arpc5 sets the stage for an elaborate translational control mechanism by facilitating […]
Human Reproduction: Parental infertility, infertility treatment and hepatoblastoma: a report from the Children’s Oncology Group
April 3, 2012
Susan E Puumala 1, Julie A Ross, James H Feusner, Gail E Tomlinson, Marcio H Malogolowkin, Mark D Krailo, Logan G Spector Abstract Background: A recent study suggested a markedly increased risk of hepatoblastoma (HB) among children conceived with treatment for infertility. However, it is not clear whether this finding is confounded by the association between HB and low birth weight (LBW). Methods: Associations […]
Experimental Hematology: Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm
April 1, 2012
Author links open overlay panelStephanie N.Zimmerab∗ Madeleine E.Lemieuxc∗ Bijal P.Kariaab ClaudiaDayb TingZhouab QingZhoub Andrew L.Kungc UthraSuresh bYidongChenbd Marsha C.Kinneye Alexander J.R.Bishopab Vivienne I.Rebel Myelodysplastic syndrome is a complex family of preleukemic diseases in which hematopoietic stem cell defects lead to abnormal differentiation in one or more blood lineages. Disease progression is associated with increased genomic […]
Journal of Clinical Oncology: Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers
March 19, 2012
Brian S Finkelman 1, Wendy S Rubinstein, Sue Friedman, Tara M Friebel, Shera Dubitsky, Niecee Singer Schonberger, Rochelle Shoretz, Christian F Singer, Joanne L Blum, Nadine Tung, Olufunmilayo I Olopade, Jeffrey N Weitzel, Henry T Lynch, Carrie Snyder, Judy E Garber, Joellen Schildkraut, Mary B Daly, Claudine Isaacs, Gabrielle Pichert, Susan L Neuhausen, Fergus J Couch, Laura van’t Veer, Rosalind Eeles, Elizabeth Bancroft, D Gareth Evans, Patricia A Ganz, Gail E Tomlinson, Steven A Narod, Ellen Matloff, Susan Domchek, Timothy R Rebbeck Abstract Purpose: Mutations in BRCA1/2 […]
Molecular Biology of the Cell: Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells
February 22, 2012
Shu Lin 1, Junhua Yang, Abdel G Elkahloun, Abhik Bandyopadhyay, Long Wang, John E Cornell, I-Tien Yeh, Joseph Agyin, Gail Tomlinson, Lu-Zhe Sun Abstract The molecular mechanisms that drive triple-negative, basal-like breast cancer progression are elusive. Few molecular targets have been identified for the prevention or treatment of this disease. Here we developed a series of isogenic basal-like human mammary epithelial cells (HMECs) with altered […]
Gastroenterology: Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival
December 3, 2011
Background & Aims Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression.
Stand Genomic Sciences: Minimum Information about a Genotyping Experiment (MIGEN)
November 30, 2011
Jie Huang, Daniel Mirel, Elizabeth Pugh, Chao Xing, Peter N Robinson, Alexander Pertsemlidis, Lianghao Ding, Julia Kozlitina, Joseph Maher, Jonathan Rios, Michael Story, Nishanth Marthandan, Richard H Scheuermann Abstract Genotyping experiments are widely used in clinical and basic research laboratories to identify associations between genetic variations and normal/abnormal phenotypes. Genotyping assay techniques vary from single genomic regions that are interrogated using PCR reactions to high throughput assays […]
Breast Cancer Research: Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
November 12, 2011
Anna Marie Mulligan 1, Fergus J Couch, Daniel Barrowdale, Susan M Domchek, Diana Eccles, Heli Nevanlinna, Susan J Ramus, Mark Robson, Mark Sherman, Amanda B Spurdle, Barbara Wappenschmidt, Andrew Lee, Lesley McGuffog, Sue Healey, Olga M Sinilnikova, Ramunas Janavicius, Thomas vO Hansen, Finn C Nielsen, Bent Ejlertsen, Ana Osorio, Iván Muñoz-Repeto, Mercedes Durán, Javier Godino, Maroulio Pertesi, Javier Benítez, Paolo Peterlongo, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Elisa Cattaneo, Bernardo Bonanni, Alessandra Viel, Barbara Pasini, Laura Papi, Laura Ottini, Antonella Savarese, Loris Bernard, Paolo Radice, Ute Hamann, Martijn Verheus, Hanne E J Meijers-Heijboer, Juul Wijnen, Encarna B Gómez […]