Research Paper

Expert Opinion on Biological Therapy: microRNA regulation of cell viability and drug sensitivity in lung cancer

June 26, 2012

Liqin Du , & Alexander Pertsemlidis Abstract Introduction:microRNAs (miRNAs) are 19 – 23 nucleotide long RNAs found in multiple organisms that regulate gene expression and have been shown to play important roles in tumorigenesis. In the context of lung cancer, numerous studies have shown that tumor suppressor genes and oncogenes that play crucial roles in […]

Transnational Cancer Research: Chain-reaction, a model of gene expression dynamics

June 21, 2012

Submitted May 21, 2012. Accepted for publication Jun 21, 2012. doi: 10.3978/j.issn.2218-676X.2012.06.01 One of the fundamental studies of transcription response to stimuli is to model the activation, repression of hundreds of genes, and their regulations. To further complicate the scenario, genes are regulated by multiple transcription factors, operating through different modes (earlier activation or secondary […]

PLoS One: miR-337-3p and Its Targets STAT3 and RAP1A Modulate Taxane Sensitivity in Non-Small Cell Lung Cancers

June 18, 2012

Liqin Du, Maria C. Subauste, Christopher DeSevo, Zhenze Zhao, Michael Baker, Robert Borkowski, Jeoffrey J. Schageman, Rachel Greer, Chin-Rang Yang, Milind Suraokar, Ignacio I. Wistuba, Adi F. Gazdar, John D. Minna, Alexander Pertsemlidis  Abstract NSCLC (non-small cell lung cancer) often exhibits resistance to paclitaxel treatment. Identifying the elements regulating paclitaxel response will advance efforts to […]

Cancer Epidemiology Biomarkers & Prevention: Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers

May 11, 2012

Amanda B Spurdle 1, Louise Marquart, Lesley McGuffog, Sue Healey, Olga Sinilnikova, Fei Wan, Xiaoqing Chen, Jonathan Beesley, Christian F Singer, Anne-Catharine Dressler, Daphne Gschwantler-Kaulich, Joanne L Blum, Nadine Tung, Jeff Weitzel, Henry Lynch, Judy Garber, Douglas F Easton, Susan Peock, Margaret Cook, Clare T Oliver, Debra Frost, Don Conroy, D Gareth Evans, Fiona Lalloo, Ros Eeles, Louise Izatt, Rosemarie Davidson, Carol Chu, Diana Eccles, Christina G Selkirk, Mary Daly, Claudine Isaacs, Dominique Stoppa-Lyonnet, Olga M Sinilnikova, Bruno Buecher, Muriel Belotti, Sylvie Mazoyer, Laure Barjhoux, Carole Verny-Pierre, Christine Lasset, Hélène Dreyfus, Pascal Pujol, Marie-Agnès Collonge-Rame, GEMO Study Collaborators; Matti A […]

Science: Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

April 13, 2012

In Hye Lee1, Yoshichika Kawai1, Maria M. Fergusson1, Ilsa I. Rovira1, Alexander J. R. Bishop2, Noboru Motoyama3, Liu Cao4,*, Toren Finkel1,* Starvation and Autophagy Starvation stimulates withdrawal from the cell cycle, as well as stimulating autophagy. Are these two events connected? Lee et al. (p. 225) show a direct and nutrient-sensitive interaction between the tumor suppressor p53 and the essential autophagy gene […]

PNAS: Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation

April 10, 2012

Yao-Fu Chang, Jennifer S. Lee-Chang, J. Saadi Imam, Kalyan Chakravarthy Buddavarapu, Sarah S. Subaran, Amiya P. Sinha-Hikim, Myriam Gorospe, and Manjeet K. Rao Abstract Decoupling of transcription and translation during postmeiotic germ cell differentiation is critical for successful spermatogenesis. Here we establish that the interaction between microRNAs and actin-associated protein Arpc5 sets the stage for an elaborate translational control mechanism by facilitating […]

Human Reproduction: Parental infertility, infertility treatment and hepatoblastoma: a report from the Children’s Oncology Group

April 3, 2012

Susan E Puumala 1, Julie A Ross, James H Feusner, Gail E Tomlinson, Marcio H Malogolowkin, Mark D Krailo, Logan G Spector Abstract Background: A recent study suggested a markedly increased risk of hepatoblastoma (HB) among children conceived with treatment for infertility. However, it is not clear whether this finding is confounded by the association between HB and low birth weight (LBW). Methods: Associations […]

Experimental Hematology: Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm

April 1, 2012

Author links open overlay panelStephanie N.Zimmerab∗  Madeleine E.Lemieuxc∗  Bijal P.Kariaab  ClaudiaDayb  TingZhouab  QingZhoub  Andrew L.Kungc  UthraSuresh  bYidongChenbd  Marsha C.Kinneye  Alexander J.R.Bishopab  Vivienne I.Rebel Myelodysplastic syndrome is a complex family of preleukemic diseases in which hematopoietic stem cell defects lead to abnormal differentiation in one or more blood lineages. Disease progression is associated with increased genomic […]

Journal of Clinical Oncology: Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers

March 19, 2012

Brian S Finkelman 1, Wendy S Rubinstein, Sue Friedman, Tara M Friebel, Shera Dubitsky, Niecee Singer Schonberger, Rochelle Shoretz, Christian F Singer, Joanne L Blum, Nadine Tung, Olufunmilayo I Olopade, Jeffrey N Weitzel, Henry T Lynch, Carrie Snyder, Judy E Garber, Joellen Schildkraut, Mary B Daly, Claudine Isaacs, Gabrielle Pichert, Susan L Neuhausen, Fergus J Couch, Laura van’t Veer, Rosalind Eeles, Elizabeth Bancroft, D Gareth Evans, Patricia A Ganz, Gail E Tomlinson, Steven A Narod, Ellen Matloff, Susan Domchek, Timothy R Rebbeck Abstract Purpose: Mutations in BRCA1/2 […]

Molecular Biology of the Cell: Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells

February 22, 2012

Shu Lin 1, Junhua Yang, Abdel G Elkahloun, Abhik Bandyopadhyay, Long Wang, John E Cornell, I-Tien Yeh, Joseph Agyin, Gail Tomlinson, Lu-Zhe Sun Abstract The molecular mechanisms that drive triple-negative, basal-like breast cancer progression are elusive. Few molecular targets have been identified for the prevention or treatment of this disease. Here we developed a series of isogenic basal-like human mammary epithelial cells (HMECs) with altered […]