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eCancer: Finding hints at novel target for Ewing sarcoma therapy
July 17, 2020
New insights into Ewing sarcoma, an aggressive childhood cancer, were published in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents.
SCIENCE DAILY: Finding hints at novel target for Ewing sarcoma therapy
July 17, 2020
Originally Published by: Science Daily New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily […]
UT Health SA Newsroom: Finding published in Nature hints at novel therapeutic target for Ewing sarcoma
July 16, 2020
New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the prestigious journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents. The […]
Alexander J.R. Bishop, DPhil. & Aparna Gorthi, PhD, Co-Author Nature Research Paper
July 15, 2020
Bishop Gorthi “Nucleolar RNA Polymerase II Drives Ribosome Biogenesis” Publication Date: July 15, 2020 Abstract Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol […]
Nature: Nucleolar RNA polymerase II drives ribosome biogenesis
July 15, 2020
Karan J. Abraham, Negin Khosraviani, Janet N. Y. Chan, Aparna Gorthi, Anas Samman, Dorothy Y. Zhao, Miling Wang, Michael Bokros, Elva Vidya, Lauren A. Ostrowski, Roxanne Oshidari, Violena Pietrobon, Parasvi S. Patel, Arash Algouneh, Rajat Singhania, Yupeng Liu, V. Talya Yerlici, Daniel D. De Carvalho, Michael Ohh, Brendan C. Dickson, Razq Hakem, Jack F. Greenblatt, […]
Oncogene: Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice (Chen Lab)
June 12, 2020
Chien-Chin Lin, Chi-Yuan Yao, Yueh-Chwen Hsu, Hsin-An Hou, Chang-Tsu Yuan, Yi-Hung Li, Chein-Jun Kao, Po-Han Chuang, Yu-Chiao Chiu, Yidong Chen, Wen-Chien Chou & Hwei-Fang Tien Abstract HOPX is a stem cell marker in hair follicles and intestines. It was shown critical for primitive hematopoiesis. We previously showed an association between higher HOPX expression and clinical characteristics related to stemness and quiescence of leukemic cells in acute myeloid […]
Clinical Cancer Research: Evaluation of Eribulin Combined with Irinotecan for Treatment of Pediatric Cancer Xenografts
June 1, 2020
Andrew J. Robles, Raushan T. Kurmasheva, Abhik Bandyopadhyay, Doris A. Phelps, Stephen W. Erickson, Zhao Lai, Dias Kurmashev, Yidong Chen, Malcom A. Smith, and Peter J. Houghton Abstract Purpose: Vincristine combined with camptothecin derivatives showed synergy in preclinical pediatric cancer models, and the combinations are effective in the treatment of childhood solid tumors. We determined whether the synergy between vincristine and irinotecan extends to eribulin, another microtubule inhibitor. Experimental Design: Vincristine or eribulin, alone or […]
Kunal Baxi, PhD to receive Translational Science Training (TST) TL1 award. (Ignatius Lab)
May 18, 2020
The Greehey Children’s Cancer Research Institute, UT Health San Antonio wishes to congratulate Kunal Baxi, PhD, from the lab of Principal Investigator, Myron Ignatius, PhD. on receiving the UT Health San Antonio, Translational Science Training (TST) TL1 award. ABOUT THE PROGRAM This program is meant to enhance the quality and scope of the doctoral/postdoctoral research experience […]
Nature Cell Biology: Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance
May 18, 2020
Mingjun Bi 1, Zhao Zhang 1, Yi-Zhou Jiang 2, Pengya Xue 1, Hu Wang 1, Zhao Lai 1, Xiaoyong Fu 3, Carmine De Angelis 3, Yue Gong 2, Zhen Gao 4, Jianhua Ruan 1 4, Victor X Jin 1, Elisabetta Marangoni 5, Elodie Montaudon 5, Christopher K Glass 6, Wei Li 7, Tim Hui-Ming Huang 1, Zhi-Ming Shao 2, Rachel Schiff 3, Lizhen Chen 8 9, Zhijie Liu 10 Abstract Acquired therapy resistance is a major problem for anticancer treatment, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model, we show that endocrine […]
Katsumi Kitagawa, Pharm.D., PhD Awarded $1M NSF Grant
March 16, 2020
Overview: Centromeres are essential for chromosome segregation during mitosis. The kinetochore is the protein complex associated with the centromere. Dysfunction in centromeres causes chromosome instability and can result in aneuploidy. The overall goal of our research is to understand the mechanisms that help maintain centromere function. Centromere identity does not rely on specific DNA sequences, […]