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Scitech Daily: SARS-CoV-2 Coronavirus Has a “Camouflage” That Causes Cells Not to Recognize It – “Fundamental Advance in Our Understanding of the Virus”

July 24, 2020

With an alarm code, we can enter a building without bells going off. It turns out that the SARS coronavirus 2 (SARS-CoV-2) has the same advantage in entering cells. It possesses the code to waltz right in. Today (July 24, 2020), in Nature Communications, researchers at The University of Texas Health Science Center at San Antonio […]


Nature Communications: Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution (Zheng)

July 22, 2020

Yinghua Li 1 2 3, Bo Li 4, Wei Li 5, Yuan Wang 1 2 3, Seçkin Akgül 1 2 3 6 7, Daniel M Treisman 1 2 3 6, Kevin A Heist 8, Brianna R Pierce 1 2 3, Benjamin Hoff 8, Cheng-Ying Ho 5, David O Ferguson 9, Alnawaz Rehemtulla 10, Siyuan Zheng 11, Brian D Ross 8, Jun Z Li 4, Yuan Zhu 12 13 14 15 16 Abstract Recent characterization of the spatiotemporal genomic architecture of IDH-wild-type multifocal glioblastomas (M-GBMs) suggests a clinically unobserved common ancestor (CA) with a less aggressive phenotype, generating highly genetically divergent malignant gliomas/GBMs in […]


eCancer: Finding hints at novel target for Ewing sarcoma therapy

July 17, 2020

New insights into Ewing sarcoma, an aggressive childhood cancer, were published in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents.


SCIENCE DAILY: Finding hints at novel target for Ewing sarcoma therapy

July 17, 2020

Originally Published by: Science Daily New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily […]


UT Health SA Newsroom: Finding published in Nature hints at novel therapeutic target for Ewing sarcoma

July 16, 2020

New insights into Ewing sarcoma, an aggressive childhood cancer, were published July 15 in the prestigious journal Nature. Researchers from the Long School of Medicine at The University of Texas Health Science Center at San Antonio contributed to the study. Ewing sarcoma is a bone and soft tissue cancer that primarily affects children and adolescents. The […]


Alexander J.R. Bishop, DPhil. & Aparna Gorthi, PhD, Co-Author Nature Research Paper

July 15, 2020

   Bishop                    Gorthi “Nucleolar RNA Polymerase II Drives Ribosome Biogenesis” Publication Date: July 15, 2020 Abstract Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol […]


Nature: Nucleolar RNA polymerase II drives ribosome biogenesis

July 15, 2020

Karan J. Abraham, Negin Khosraviani, Janet N. Y. Chan, Aparna Gorthi, Anas Samman, Dorothy Y. Zhao, Miling Wang, Michael Bokros, Elva Vidya, Lauren A. Ostrowski, Roxanne Oshidari, Violena Pietrobon, Parasvi S. Patel, Arash Algouneh, Rajat Singhania, Yupeng Liu, V. Talya Yerlici, Daniel D. De Carvalho, Michael Ohh, Brendan C. Dickson, Razq Hakem, Jack F. Greenblatt, […]


Oncogene: Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice (Chen Lab)

June 12, 2020

Chien-Chin Lin, Chi-Yuan Yao, Yueh-Chwen Hsu, Hsin-An Hou, Chang-Tsu Yuan, Yi-Hung Li, Chein-Jun Kao, Po-Han Chuang, Yu-Chiao Chiu, Yidong Chen, Wen-Chien Chou & Hwei-Fang Tien Abstract HOPX is a stem cell marker in hair follicles and intestines. It was shown critical for primitive hematopoiesis. We previously showed an association between higher HOPX expression and clinical characteristics related to stemness and quiescence of leukemic cells in acute myeloid […]


Clinical Cancer Research: Evaluation of Eribulin Combined with Irinotecan for Treatment of Pediatric Cancer Xenografts

June 1, 2020

Andrew J. Robles, Raushan T. Kurmasheva, Abhik Bandyopadhyay, Doris A. Phelps, Stephen W. Erickson, Zhao Lai, Dias Kurmashev, Yidong Chen, Malcom A. Smith, and Peter J. Houghton Abstract Purpose: Vincristine combined with camptothecin derivatives showed synergy in preclinical pediatric cancer models, and the combinations are effective in the treatment of childhood solid tumors. We determined whether the synergy between vincristine and irinotecan extends to eribulin, another microtubule inhibitor. Experimental Design: Vincristine or eribulin, alone or […]


Kunal Baxi, PhD to receive Translational Science Training (TST) TL1 award. (Ignatius Lab)

May 18, 2020

The Greehey Children’s Cancer Research Institute, UT Health San Antonio wishes to congratulate Kunal Baxi, PhD, from the lab of Principal Investigator, Myron Ignatius, PhD. on receiving the UT Health San Antonio, Translational Science Training (TST) TL1 award.  ABOUT THE PROGRAM This program is meant to enhance the quality and scope of the doctoral/postdoctoral research experience […]