Oncogene: Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice (Chen Lab)

June 12, 2020

Chien-Chin Lin, Chi-Yuan Yao, Yueh-Chwen Hsu, Hsin-An Hou, Chang-Tsu Yuan, Yi-Hung Li, Chein-Jun Kao, Po-Han Chuang, Yu-Chiao Chiu, Yidong Chen, Wen-Chien Chou & Hwei-Fang Tien Abstract HOPX is a stem cell marker in hair follicles and intestines. It was shown critical for primitive hematopoiesis. We previously showed an association between higher HOPX expression and clinical characteristics related to stemness and quiescence of leukemic cells in acute myeloid […]

Clinical Cancer Research: Evaluation of Eribulin Combined with Irinotecan for Treatment of Pediatric Cancer Xenografts

June 1, 2020

Andrew J. Robles, Raushan T. Kurmasheva, Abhik Bandyopadhyay, Doris A. Phelps, Stephen W. Erickson, Zhao Lai, Dias Kurmashev, Yidong Chen, Malcom A. Smith, and Peter J. Houghton Abstract Purpose: Vincristine combined with camptothecin derivatives showed synergy in preclinical pediatric cancer models, and the combinations are effective in the treatment of childhood solid tumors. We determined whether the synergy between vincristine and irinotecan extends to eribulin, another microtubule inhibitor. Experimental Design: Vincristine or eribulin, alone or […]

Kunal Baxi, PhD to receive Translational Science Training (TST) TL1 award. (Ignatius Lab)

May 18, 2020

The Greehey Children’s Cancer Research Institute, UT Health San Antonio wishes to congratulate Kunal Baxi, PhD, from the lab of Principal Investigator, Myron Ignatius, PhD. on receiving the UT Health San Antonio, Translational Science Training (TST) TL1 award.  ABOUT THE PROGRAM This program is meant to enhance the quality and scope of the doctoral/postdoctoral research experience […]

Nature Cell Biology: Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance

May 18, 2020

Mingjun Bi 1, Zhao Zhang 1, Yi-Zhou Jiang 2, Pengya Xue 1, Hu Wang 1, Zhao Lai 1, Xiaoyong Fu 3, Carmine De Angelis 3, Yue Gong 2, Zhen Gao 4, Jianhua Ruan 1 4, Victor X Jin 1, Elisabetta Marangoni 5, Elodie Montaudon 5, Christopher K Glass 6, Wei Li 7, Tim Hui-Ming Huang 1, Zhi-Ming Shao 2, Rachel Schiff 3, Lizhen Chen 8 9, Zhijie Liu 10 Abstract Acquired therapy resistance is a major problem for anticancer treatment, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model, we show that endocrine […]

Katsumi Kitagawa, Pharm.D., PhD Awarded $1M NSF Grant

March 16, 2020

Overview: Centromeres are essential for chromosome segregation during mitosis. The kinetochore is the protein complex associated with the centromere. Dysfunction in centromeres causes chromosome instability and can result in aneuploidy. The overall goal of our research is to understand the mechanisms that help maintain centromere function. Centromere identity does not rely on specific DNA sequences, […]

Greehey CCRI Receives Its First NIH K99 Award (Chen Lab)

March 2, 2020

      Yu-Chiao Chiu, PhD, a postdoctoral researcher at the Greehey Children’s Cancer Research Institute (GCCRI), received the prestigious NIH Pathway to Independence Award (K99/R00) from the National Cancer Institute (NCI). The highly competitive NIH grant is awarded to about 30 outstanding cancer researchers nationwide each year for them to complete mentored training (K99 […]

Future Focus: San Antonio lands one of its largest Cancer Grants to Bring in New Talent

February 27, 2020

CPRIT officials said this is one of the largest amounts San Antonio institutions have collectively received from the institute in a single funding round since it was established by Texas voters in 2007. CPRIT CEO Wayne Roberts said it’s also further indication that the Alamo City “continues to expand its cancer research and prevention prowess.”