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Pertsemlidis Lab Awarded American Lung Association Grant to Study “Identifying Exploitable Biomarkers of Lung Cancer Metastasis”
June 16, 2021
Abstract Rationale. Most cancer deaths are caused by metastatic disease, and the prevention of metastasis is a significant focus of clinical research. Aberrant expression of miRNAs has been found in all cancers, yielding insights into disease processes that would be difficult to detect by other methods and revealing fundamental therapeutic vulnerabilities. miRNAs have been shown […]
St. Baldrick’s: Checking the Life-Threatening Box: A Survivor’s Update (Aune)
June 16, 2021
A childhood cancer survivor himself, Gregory J. Aune, MD, PhD, shares his personal experience and thoughts during National Cancer Survivor Month. (Originally posted on Medium on May 19th, Dr. Aune graciously agreed to share this with St. Baldrick’s.) Dr. Aune was a St. Baldrick’s Scholar 2014 – 2019, serves as […]
Greehey CCRI’s Genomic Sequencing Facility to Receive $600,000 NIH Grant to upgrade genomic sequencing capabilities (Lai Lab).
June 15, 2021
Dr. Zhao Lai, Director of the Genomic Sequencing Facility (GSF) at the Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio (UTHSA), has been awarded a $600,000 NIH grant to help purchase a new Illumina NovaSeq 6000. This new system will improve the range of basic, translational, clinical, and genomics studies at […]
Nature Communications: Metal ions help COVID-19 virus to disguise itself (Gupta Lab)
June 2, 2021
SAN ANTONIO (June 2, 2021) — Scientists from The University of Texas Health Science Center at San Antonio (Gupta Lab) and other collaborators have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions — positively charged atoms such as magnesium, manganese, […]
NIH Grant Awarded to Collaborative Team to Eradicate Ewing Sarcoma (Aune)
May 13, 2021
Despite the breakthroughs being made in treating many cancers with less toxic, targeted, and immune-based therapies, Ewing sarcoma’s 40-year-old chemotherapy regimen remains a significant contributor to mortality and long-term cardiovascular complications adolescent and young adult cancer patients. An ongoing collaborative project initiated by the Rutledge Cancer Foundation collaborates with Qana Therapeutics, Greehey Children’s Cancer Research […]
International Journal of Molecular Sciences: A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes (Rao Lab)
April 30, 2021
Raushanara Akter 1, Afrina Afrose 1, Md Rashidur Rahman 2, Rakhi Chowdhury 1, Saif Shahriar Rahman Nirzhor 3, Rubayat Islam Khan 4, Md Tanvir Kabir 1 ABSTRACT Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by […]
Nighat Noureen, PhD, Awarded CPRIT Postdoctoral Training Award (Zheng Lab)
March 10, 2021
Congratulations to Nighat Noureen, PhD, a postdoctoral fellow in the lab of Greehey CCRI principal investigator, Siyuan Zheng, PhD, on recently being awarded a CPRIT fellowship training grant. Dr. Noureen joined Dr. Zheng’s lab in June 2018. Her first project was to develop a computational method to quantify telomerase activity in cancer and […]
Dr. Yogesh Gupta Delivers COVID Presentation to International Society for Stem Cell Research
February 26, 2021
On February 25, 2021, Dr. Yogesh Gupta delivered an invited talk at the International Society for Stem Cell Research COVID network meeting chaired by Hans-Willem Snoeck. MD, PhD (Columbia Univ.) and Todd McDevitt, PhD (Gladstone Inst., UCSF). At this meeting, Dr. Gupta presented his recent research on nonstructural proteins (nsps) of SARS-CoV-2. Some […]
Cancer Letters: Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling (Chen)
February 19, 2021
Author links open overlay panels high-BoHuanga, D.Thapaa, A.R.Munoza, S.S.Hussaina, X.Yanga, R.G.Bedollaa, P.Osmulskib, M.E.Gaczynskab, Z.Laibg, Yu-ChiaoChiug, Li-JuWanggY.Chendfg, P.Rivasa, C.Shuddea, R.L.Reddickc, H.Miyamotoh, R.Ghoshabf, A.P.Kumarabef1 Shih-Bo, HuangaD.Thapaa, A.R.Munoza, S.S.Hussaina , X.YangaR. G.BedollaaP. Osmulskib M.E.GaczynskabZ.LaibgYu-ChiaoChiugLi-JuWanggY.ChendfgP.RivasaC.ShuddeaR.L.ReddickcH.MiyamotohR.GhoshabfA.P.Kumarabef1 Highlights • High nuclear SIRT1 (nSIRT1) levels were associated with a significantly increased risk of prostate cancer progression. • Androgen deplete conditions increased nuclear […]
Methods: Prediction and interpretation of cancer survival using graph convolution neural networks (Chen)
January 21, 2021
RicardoRamireza, Yu-ChiaoChiub, SongYaoZhangc, JoshuaRamireza, YidongChenbd, YufeiHuangad, Yu-FangJina Highlights • Predicting cancer survival outcomes using Graph Convolutional Neural Networks with TCGA dataset. • Combining clinical data and the GCNN improves cancer prognostic prediction. • Interpreting the GCNN model and identifying significant genes with network modules identified by HotNet2. Abstract The survival rate of cancer has increased […]