Category
June 15, 2021
Dr. Zhao Lai, Director of the Genomic Sequencing Facility (GSF) at the Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio (UTHSA), has been awarded a $600,000 NIH grant to help purchase a new Illumina NovaSeq 6000. This new system will improve the range of basic, translational, clinical, and genomics studies at […]
June 2, 2021
SAN ANTONIO (June 2, 2021) — Scientists from The University of Texas Health Science Center at San Antonio (Gupta Lab) and other collaborators have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions — positively charged atoms such as magnesium, manganese, […]
May 13, 2021
Despite the breakthroughs being made in treating many cancers with less toxic, targeted, and immune-based therapies, Ewing sarcoma’s 40-year-old chemotherapy regimen remains a significant contributor to mortality and long-term cardiovascular complications adolescent and young adult cancer patients. An ongoing collaborative project initiated by the Rutledge Cancer Foundation collaborates with Qana Therapeutics, Greehey Children’s Cancer Research […]
April 30, 2021
Raushanara Akter 1, Afrina Afrose 1, Md Rashidur Rahman 2, Rakhi Chowdhury 1, Saif Shahriar Rahman Nirzhor 3, Rubayat Islam Khan 4, Md Tanvir Kabir 1 ABSTRACT Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by […]
March 10, 2021
Congratulations to Nighat Noureen, PhD, a postdoctoral fellow in the lab of Greehey CCRI principal investigator, Siyuan Zheng, PhD, on recently being awarded a CPRIT fellowship training grant. Dr. Noureen joined Dr. Zheng’s lab in June 2018. Her first project was to develop a computational method to quantify telomerase activity in cancer and […]
February 26, 2021
On February 25, 2021, Dr. Yogesh Gupta delivered an invited talk at the International Society for Stem Cell Research COVID network meeting chaired by Hans-Willem Snoeck. MD, PhD (Columbia Univ.) and Todd McDevitt, PhD (Gladstone Inst., UCSF). At this meeting, Dr. Gupta presented his recent research on nonstructural proteins (nsps) of SARS-CoV-2. Some […]
February 19, 2021
Author links open overlay panels high-BoHuanga, D.Thapaa, A.R.Munoza, S.S.Hussaina, X.Yanga, R.G.Bedollaa, P.Osmulskib, M.E.Gaczynskab, Z.Laibg, Yu-ChiaoChiug, Li-JuWanggY.Chendfg, P.Rivasa, C.Shuddea, R.L.Reddickc, H.Miyamotoh, R.Ghoshabf, A.P.Kumarabef1 Shih-Bo, HuangaD.Thapaa, A.R.Munoza, S.S.Hussaina , X.YangaR. G.BedollaaP. Osmulskib M.E.GaczynskabZ.LaibgYu-ChiaoChiugLi-JuWanggY.ChendfgP.RivasaC.ShuddeaR.L.ReddickcH.MiyamotohR.GhoshabfA.P.Kumarabef1 Highlights • High nuclear SIRT1 (nSIRT1) levels were associated with a significantly increased risk of prostate cancer progression. • Androgen deplete conditions increased nuclear […]
January 21, 2021
RicardoRamireza, Yu-ChiaoChiub, SongYaoZhangc, JoshuaRamireza, YidongChenbd, YufeiHuangad, Yu-FangJina Highlights • Predicting cancer survival outcomes using Graph Convolutional Neural Networks with TCGA dataset. • Combining clinical data and the GCNN improves cancer prognostic prediction. • Interpreting the GCNN model and identifying significant genes with network modules identified by HotNet2. Abstract The survival rate of cancer has increased […]
January 12, 2021
Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow & Siyuan Zheng Abstract Active telomerase is essential for stem cells and most cancers to maintain telomeres. The enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the catalytic subunit of the complex. Here we […]
November 19, 2020
Wayne T. Muraoka, Anna A. Korchagina, Qingqing Xia, Sergey A. Shein, Xi Jing, Zhao Lai, Korri S. Weldon, Li-Ju Wang, Yidong Chen, Lawrence W. Kummer, Markus Mohrs, Eric Vivier, Ekaterina P. Koroleva & Alexei V. Tumanov Abstract Innate lymphoid cells (ILCs) are a heterogeneous family of immune regulators that protect against mucosal pathogens but can also […]