Featured news
Nature Cell Biology: Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance
May 18, 2020
Mingjun Bi 1, Zhao Zhang 1, Yi-Zhou Jiang 2, Pengya Xue 1, Hu Wang 1, Zhao Lai 1, Xiaoyong Fu 3, Carmine De Angelis 3, Yue Gong 2, Zhen Gao 4, Jianhua Ruan 1 4, Victor X Jin 1, Elisabetta Marangoni 5, Elodie Montaudon 5, Christopher K Glass 6, Wei Li 7, Tim Hui-Ming Huang 1, Zhi-Ming Shao 2, Rachel Schiff 3, Lizhen Chen 8 9, Zhijie Liu 10 Abstract Acquired therapy resistance is a major problem for anticancer treatment, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model, we show that endocrine […]
Katsumi Kitagawa, Pharm.D., PhD Awarded $1M NSF Grant
March 16, 2020
Overview: Centromeres are essential for chromosome segregation during mitosis. The kinetochore is the protein complex associated with the centromere. Dysfunction in centromeres causes chromosome instability and can result in aneuploidy. The overall goal of our research is to understand the mechanisms that help maintain centromere function. Centromere identity does not rely on specific DNA sequences, […]
Greehey CCRI Receives Its First NIH K99 Award (Chen Lab)
March 2, 2020
Yu-Chiao Chiu, PhD, a postdoctoral researcher at the Greehey Children’s Cancer Research Institute (GCCRI), received the prestigious NIH Pathway to Independence Award (K99/R00) from the National Cancer Institute (NCI). The highly competitive NIH grant is awarded to about 30 outstanding cancer researchers nationwide each year for them to complete mentored training (K99 […]
Future Focus: San Antonio lands one of its largest Cancer Grants to Bring in New Talent
February 27, 2020
CPRIT officials said this is one of the largest amounts San Antonio institutions have collectively received from the institute in a single funding round since it was established by Texas voters in 2007. CPRIT CEO Wayne Roberts said it’s also further indication that the Alamo City “continues to expand its cancer research and prevention prowess.”
Manjeet Rao, PhD, Awarded NCI, R01 Grant to Test Efficacy of Novel Drug
February 25, 2020
Dr. Manjeet Rao, Greehey CCRI Deputy Director (interim), was recently awarded a grant from National Cancer Institute ($2.1 million) to test the therapeutic efficacy of a novel drug that can inhibit the function of a protein that is highly expressed in cancers. Cancer cells use various mechanisms to manage their survival such as repairing DNA […]
Greehey CCRI Faculty Awarded $1.2M CPRIT Grant to Support Osteosarcoma Research
February 24, 2020
Written by: Will Sansom An award of $1.2 million from the Cancer Prevention and Research Institute of Texas (CPRIT) went to Greehey CCRI Deputy Director and principal investigator Manjeet Rao, PhD, professor of cell systems and anatomy, for studies of an enzyme protein that helps osteosarcoma cells to survive and spread. The team, which includes co-principal investigator Yogesh Gupta, […]
Luiz O.F. Penalva, PhD, Co-corresponding Senior Author on NPJ Genomic Medicine publication.
February 22, 2020
“Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles” Abstract Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecular characterization of GSCs is needed to develop more effective therapies. We conducted a study to identify differences in the splicing […]
San Antonio Business Journals: San Antonio lands one of its largest cancer grant allocations ever to bring in more talent
February 20, 2020
CPRIT officials said this is one of the largest collective awards the Alamo City has received in a single funding round.
Technology News Network: Team Develop Drugs To Fight Leukemia and Lymphoma
December 9, 2019
UT Health San Antonio researchers, working with collaborators at the University of Florida, have discovered a safe and potent next generation of drugs to fight multiple types of leukemia and lymphoma in adults and children. The journal Nature Medicine reported the findings Dec. 2. “This is a new class of drugs called PROTACs that target […]