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MDPI: MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation
December 5, 2020
Rebecca Pötschke 1,2,† Jacob Haase 1,†, Markus Glaß 1 Sebastian Simmermacher 3,Claudia Misiak 1,Luiz O. F. Penalva 4,5 Caspar D. Kühnöl, 2 and Stefan Hüttelmaier 1, Simple Summary Glioblastoma (GBM) is the most lethal brain tumor with a median survival rate of approximately 14 months. GBM patients commonly suffer from tumor recurrence, indicating that populations of chemo/radio-resistant stem cell-like tumor cells […]
Molecular Oncology: Interaction of transcription factor AP‐2 gamma with proto‐oncogene PELP1 promotes tumorigenesis by enhancing RET signaling
December 2, 2020
Junhao Liu, Zexuan Liu, Mengxing Li, , Weiwei Tang, Uday P. Pratap, Yiliao Luo, Kristin A. Altwegg, Xiaonan Li, Yi Zou, Hong Zhu, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi Abstract A significant proportion of estrogen receptor‐positive (ER+) breast cancer (BC) initially responds to endocrine therapy but eventually evolves into therapy‐resistant BC. Transcription factor AP‐2 gamma (TFAP2C) is a known regulator of ER […]
PNAS: Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility
November 24, 2020
Yuan Lu, View ORCID ProfileAngel Sandoval, View ORCID ProfileSarah Voss, Zhao Lai, Susanne Kneitz, Will Boswell, Mikki Boswell, Markita Savage, View ORCID ProfileChristi Walter, Wes Warren, View ORCID ProfileManfred Schartl, and Ronald Walter Abstract Mixing genomes of different species by hybridization can disrupt species-specific genetic interactions that were adapted and fixed within each species population. Such disruption can predispose the hybrids to abnormalities and disease that […]
Mucosal Immunology: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion
November 19, 2020
Wayne T. Muraoka, Anna A. Korchagina, Qingqing Xia, Sergey A. Shein, Xi Jing, Zhao Lai, Korri S. Weldon, Li-Ju Wang, Yidong Chen, Lawrence W. Kummer, Markus Mohrs, Eric Vivier, Ekaterina P. Koroleva & Alexei V. Tumanov Abstract Innate lymphoid cells (ILCs) are a heterogeneous family of immune regulators that protect against mucosal pathogens but can also […]
Nature Communications: Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells (Pertsemlidis)
November 16, 2020
Justin B. Moroney, Anusha Vasudev, Alexander Pertsemlidis, Hong Zan & Paolo Casali Abstract Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B cells (NBC), IgD+ unswitched (unsw)MBCs, and IgG+ or IgA+ class-switched (sw)MBCs from humans of different age, sex and race. Conserved antibody variable gene expression […]
Argonne National Laboratory: Hide and Seek: Understanding How COVID-19 Evades Detection in a Human Cell (Gupta)
November 3, 2020
BY ANDRE SALLES |OCTOBER 29, 2020 Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body. Scientists around the world have been working for months to identify and develop treatments that combat SARS-CoV-2, the virus that causes COVID-19. An important part of that process […]
Cell Reports: GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth
November 3, 2020
Fuchun Zhou (1), David J.Elzi (1, 2), Panneerselvam Jayabal(1), Xiuye Ma(1), Yu-Chiao Chiu (1) Yidong Chen 1,3,4) Barron Blackman(1) Susan T.Weintraub (4, 5) Peter J.Houghton 1,4,6) Yuzuru Shiio (1,4,5,7) Highlights The autocrine signaling mediated by GDF6 maintains Ewing sarcoma growth The GDF6 prodomain is a ligand for CD99, a widely used marker for Ewing sarcoma […]
ECancer Interview: Prospective validation of single mouse testing by the paediatric preclinical testing consortium (Houghton)
October 24, 2020
Dr. Peter Houghton speaks to ecancer about the prospective validation of single mouse testing by the pediatric preclinical testing consortium; a study that was presented at ENA 2020 this year. Dr. Houghton initially explains the rationale behind this study and talks about how it was tested that using a single mouse for studying drug efficacy [...]MedicalXpress – One Mouse at a Time: a New Approach to Testing Potential Drugs for Children’s Cancers (Houghton, Kurmasheva, PPTC)
October 22, 2020
by European Organisation for Research and Treatment of Cancer A team of researchers in the US and Australia have developed a way of testing potential drugs for children’s cancers so as to take account of the wide genetic diversity of these diseases. In new research to be presented at the 32nd EORTC-NCI-AACR Symposium on Molecular […]
Breast Cancer Research and Treatment: KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer
October 14, 2020
Abstract Purpose Cancer stem cells (CSCs) are highly tumorigenic, spared by chemotherapy, sustain tumor growth, and are implicated in tumor recurrence after conventional therapies in triple-negative breast cancer (TNBC). Lysine-specific histone demethylase 1A (KDM1A) is highly expressed in several human malignancies and CSCs including TNBC. However, the precise mechanistic role of KDM1A in CSC functions […]