European Journal of Cancer: Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

December 6, 2021

Elvira C.van Dalena Renée L.Muldera EugeneSuhb Matthew J.Ehrhardtc Gregory J.Auned Bradley J.Bensong JuttaBergler-Kleinh Ming H.Cheni EvaFreyf UlrikeHennewigj LianeLockwoodk UllaMartinssonl MonicaMuracam Helenavan der Pala ChrisPlummern KatrinScheinemannopq ChristinaSchinderars Daniel A.Mulrooneyc Highlights • Cancer survivors are at risk for premature coronary artery disease (CAD). • Especially survivors treated with radiotherapy exposing the heart. • This guideline provides recommendations [...]

Journal of Trauma & Acute Care Surgery: Whole Blood Resuscitation Restores Intestinal Perfusion and Influences Gut Microbiome Diversity (Lai)

August 24, 2021

Yracheta, Jaclyn MD1; Muraoka, Wayne PhD2; Wu, Xiaowu MD2; Burmeister, David PhD3; Darlington, Daniel PhD2; Zhao, David MD2; Lai, Zhao PhD4; Scroggins, Shannon MS1; Cap, Andrew P. MD, PhD2; Bynum, James PhD2; Nicholson, Susannah E. MD1,2 Abstract Objective Gut dysbiosis, an imbalance in the gut microbiome, occurs after trauma which may be ameliorated with transfusion. We […]

UT Health San Antonio holds first all-school commencement

May 25, 2021

For the first time in its 53-year history, UT Health San Antonio celebrated a combined, all-school commencement May 22 at the Alamodome.

BMC Bioinformatics – Correlation AnalyzeR: Functional Predictions from Gene Co-Expression Correlations (Bishop Lab)

April 21, 2021

Henry E. Miller, Alexander J. R. Bishop Abstract Background Co-expression correlations provide the ability to predict gene functionality within specific biological contexts, such as different tissue and disease conditions. However, current gene co-expression databases generally do not consider the biological context. In addition, these tools often implement a limited range of unsophisticated analysis approaches, diminishing […]

Dr. Yogesh Gupta Delivers COVID Presentation to International Society for Stem Cell Research

February 26, 2021

    On February 25, 2021, Dr. Yogesh Gupta delivered an invited talk at the International Society for Stem Cell Research COVID network meeting chaired by Hans-Willem Snoeck. MD, PhD (Columbia Univ.) and Todd McDevitt, PhD (Gladstone Inst., UCSF). At this meeting, Dr. Gupta presented his recent research on nonstructural proteins (nsps) of SARS-CoV-2. Some […]

FASEB Journal: Identification of a novel mechanism for meso‐tetra (4‐carboxyphenyl) porphyrin (TCPP) uptake in cancer cells

February 25, 2021

            David J. Elzi,   William E. Bauta,  Jamila R. Sanchez,  Trisha Das, Shweta Mogare, Peter Zannes Fatland,  Moises Iza, Alexander Pertsemlidis,  Vivienne I. Rebel  Abstract Porphyrins are used for cancer diagnostic and therapeutic applications, but the mechanism of how porphyrins accumulate in cancer cells remains elusive. Knowledge of how porphyrins […]

Cancer Research: A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models (Houghton, Kurmasheva)

February 19, 2021

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan T. Kurmasheva, Morgan Diolaiti, Alan Ashworth, Cody J. Peer, Ryan Nguyen, William D. Figg Sr., Denis R. Beckford-Vera, and Daniel V. Santi Abstract PARP inhibitors are approved for the treatment of cancers with BRCA1 or BRCA2 defects. In this study, we prepared and characterized a […]

Clinical Cancer Research: The B7-H3-targeting antibody-drug conjugate m276-SL-PBD is potently effective against pediatric cancer preclinical solid tumor models

February 15, 2021

Nathan M. Kendsersky, Jarrett M Lindsay, Edward A. Kolb, Malcolm A. Smith, Beverly A. Teicher, Stephen Erickson, Eric J Earley, Yaël P. Mossé, Daniel Martinez, Jennifer Pogoriler, Kateryna Krytska, Khushbu Patel, David Groff, Matthew Tsang, Samson Ghilu, Yifei Wang, Steven Seaman, Yang Feng, Brad St. Croix, Richard Gorlick, Raushan T. Kurmasheva, Peter J. Houghton and John M. Maris Abstract Purpose: Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by the CD276 gene that is overexpressed in many pediatric cancers. Here, we investigate the […]

Cell Press: A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity (Zheng Lab)

January 21, 2021

Evan O.Paull114,  Alvaro Aytes121314,  Sunny J.Jones114,  Prem S.Subramaniam1,  Federico M.Giorgi3,  Eugene F.Douglass1,  Somnath Tagore1,  Brennan Chu1,  Alessandro Vasciaveo1,  Siyuan Zheng4,  Roel Verhaak5,  Cory Abate-Shen1678,  Mariano J.Alvarez19,  Andrea Califano16910111215 Summary Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a network-based approach, identified 407 […]

Methods: Prediction and interpretation of cancer survival using graph convolution neural networks (Chen)

January 21, 2021

RicardoRamireza, Yu-ChiaoChiub, SongYaoZhangc, JoshuaRamireza, YidongChenbd, YufeiHuangad, Yu-FangJina Highlights •  Predicting cancer survival outcomes using Graph Convolutional Neural Networks with TCGA dataset. •  Combining clinical data and the GCNN improves cancer prognostic prediction. •  Interpreting the GCNN model and identifying significant genes with network modules identified by HotNet2. Abstract The survival rate of cancer has increased […]