All News
Cardiovascular Business: Chemotherapy could be damaging children’s heart cells, leading to problems later in life (Aune)
September 30, 2020
Undergoing chemotherapy can have a negative impact on the cells responsible for repairing heart damage, according to a new study published in PLOS One. This may explain why 20% of children treated with anthracyclines go on to experience heart failure later in life. “We don’t fully understand why some children who are exposed to anthracycline therapy […]
Medical Xpress: Childhood Chemo Alters Heart’s Caretaker Cells, Study Finds (Aune Lab)
September 30, 2020
by Will Sansom, UT Health San Antonio Cancer chemotherapy changes the function of cells that repair heart injury, researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) discovered. Twenty percent of children treated with drugs called anthracyclines go on to suffer heart failure later in life. The journal […]
Scientific Reports: “Transcriptomic Sex Differences in Sensory Neuronal Populations of Mice”
September 23, 2020
Jennifer Mecklenburg 1, Yi Zou 2, Andi Wangzhou 3, Dawn Garcia 2, Zhao Lai 2 4, Alexei V Tumanov 5, Gregory Dussor 3, Theodore J Price 3, Armen N Akopian 6 7 Abstract Many chronic pain conditions show sex differences in their epidemiology. This could be attributed to the sex-dependent differential expression of genes (DEGs) involved in nociceptive pathways, including sensory neurons. This study aimed to identify sex-dependent DEGs in estrous female versus male […]
PLOS One: Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts (Aune)
September 22, 2020
T. R. Mancilla, L. R. Davis, G. J. Aune Abstract Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast majority of long-term childhood cancer survivors will develop a chronic health condition caused by their successful treatments and severe cardiac disease is a common life-threatening outcome […]
Scientific Reports: Transcriptomic sex differences in sensory neuronal populations of mice
September 17, 2020
Jennifer Mecklenburg 1, Yi Zou 2, Andi Wangzhou 3, Dawn Garcia 2, Zhao Lai 2 4, Alexei V Tumanov 5, Gregory Dussor 3, Theodore J Price 3, Armen N Akopian 6 7 Abstract Many chronic pain conditions show sex differences in their epidemiology. This could be attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive pathways, including sensory neurons. This study aimed to identify sex-dependent DEGs in estrous female versus male sensory […]
Raushan Kurmasheva, PhD, Part of Dmitri Ivanov, PhD, CPRIT Grant Team “Identifying and Optimizing Small Molecules for Drug Development.
September 8, 2020
SOURCE: UT Health San Antonio Newsroom “The following are the additional researchers and their awards: Dmitri Ivanov, PhD, associate professor of biochemistry and structural biology, will receive an Individual Investigator Research Award for Cancer in Children and Adolescents in the amount of $1,198,659. The topic is “Enhancing Cytarabine Response Through SAMHD1 Inhibition.” Dr. Ivanov’s team […]
Nucleic Acids Research: “PCAT: an Integrated Portal for Genomic and Preclinical Testing Data of Pediatric Cancer Patient-Derived Xenograft Models” in Oxford Academic (multiple faculty and researchers)
September 8, 2020
Juechen Yang, Qilin Li, Nighat Noureen (Greehey CCRI, Zheng Lab), Yanbing Fang, Raushan Kurmasheva (Greehey CCRI, Kurmasheva Lab), Peter J Houghton (Greehey CCRI, Houghton Lab), Xiaojing Wang (Greehey CCRI, Wang Lab), Siyuan Zheng (Greehey CCRI, Zheng Lab) Nucleic Acids Research, gkaa698, https://doi.org/10.1093/nar/gkaa698 Published: 18 August 2020 Abstract Although cancer is the leading cause of disease-related mortality in […]
Ignatius Lab and Team “GCCRI Goes the Extra Mile” Organizing Local Alex’s Lemonade Stand “Million Mile” Virtual Event
September 3, 2020
It’s that time of year again where we tell everyone what we do. We also remember the children with cancer and know your research will make a difference. Join us again this year for The Million Mile this September to raise awareness for Childhood Cancer Awareness Month! Last year, we raised over $3,000 for Alex’s […]
KABB Fox29: SA STRONG: Local doctor beats cancer, now changing lives of young patients (Aune Lab)
August 27, 2020
A UT Health San Antonio doctor who beat cancer is on a mission to help young cancer patients. Dr. Greg Aune, UT Health San Antonio Pediatric Oncologist, is recalling his days as a young athlete. “My sophomore year of high school I was playing a lot of sports. I played football that year,” said Dr. Aune. He […]
Henry Miller (Bishop Lab) Receives Greehey Graduate Fellowship in Children’s Health
August 26, 2020
Henry Miller has just received the Greehey Graduate Fellowship Award in Children’s Health. Miller is a student in the Biology of Aging discipline of the Integrated Biomedical Sciences program in the lab of Dr. Alex Bishop. The Greehey Graduate Fellowship Award in Children’s Health was established by the Greehey family to support students who wish to pursue graduate […]