All News
Advanced Photon Source: How SARS-CoV-2 RNA Evades Host Immune Responses (Gupta Lab)
August 26, 2020
As we all know too well, the virus SARS-CoV-2 causes severe respiratory illness COVID-19. In parallel with the critical search for a cure, scientists are working diligently to develop effective treatments that can help lower the morbidity of this deadly virus. To develop these therapeutics, we must understand how the virus is able to invade […]
Luiz O.F. Penalva PhD Awarded CPRIT Grant to Study New Glioblastoma (GBM) Regulator
August 20, 2020
PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alterations have been disappointing. To build an alternative route, we have been focusing on oncogenic RNA binding […]
Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.
August 20, 2020
Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory networks provide new opportunities for targeted therapy. Results We identify the RNA-binding protein SERBP1 […]
Physician’s Weekly: PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models.
August 20, 2020
Although cancer is the leading cause of disease-related mortality in children, the relative rarity of pediatric cancers poses a significant challenge for developing novel therapeutics to further improve prognosis. Patient-derived xenograft (PDX) models, which are usually developed from high-risk tumors, are a useful platform to study molecular driver events, identify biomarkers and prioritize therapeutic agents.
Cellular and Molecular Bioengineering: Scaffold Architecture and Matrix Strain Modulate Mesenchymal Cell and Microvascular Growth and Development in a Time Dependent Manner
August 18, 2020
2020 CMBE Young Innovators issue Gennifer Chiou, Elysa Jui, Allison C. Rhea, Aparna Gorthi, Solaleh Miar, Francisca M. Acosta, Cynthia Perez, Yasir Suhail, Kshitiz, Yidong Chen, Joo L. Ong, Rena Bizios, Christopher Rathbone & Teja Guda Abstract Background Volumetric tissue-engineered constructs are limited in development due to the dependence on well-formed vascular networks. Scaffold pore size […]
PIPETTE GAZETTE: CSA Shoutout to Graduating Student Pooja Yadav (Rao Lab)
August 11, 2020
Congratulations to one of our CSA graduate students Pooja Yadav, M.S. (Cancer Biology discipline) who successfully defended her PhD dissertation on June 25!
Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation (Bishop & Penalva Labs)
August 6, 2020
Adam Kosti 1 2, Patricia Rosa de Araujo 1 2, Wei-Qing Li 1 3, Gabriela D A Guardia 4, Jennifer Chiou 5, Caihong Yi 1, Debashish Ray 6, Fabiana Meliso 4, Yi-Ming Li 3, Talia Delambre 1, Mei Qiao 1, Suzanne S Burns 1, Franziska K Lorbeer 1, Fanny Georgi 1, Markus Flosbach 1, Sarah Klinnert 1, Anne Jenseit 1, Xiufen Lei 1, Carolina Romero Sandoval 1, Kevin Ha 6, Hong Zheng 6, Renu Pandey 1, Aleksandra Gruslova 7, Yogesh K Gupta 1, Andrew Brenner 8, Erzsebet Kokovay 2, Timothy R Hughes 6 9 10, Quaid D Morris 6 9 11, Pedro A F Galante 12, Stefano Tiziani 13, Luiz O F Penalva 14 15 Abstract Background: RNA-binding proteins (RBPs) function as master regulators […]
Health 24: How the coronavirus infects: It can make itself unrecognisable to cells in the body
August 5, 2020
Like a thief in the night, Covid-19 can disguise itself to easily enter and infect cells in the human body. A new research study details what cells are more susceptible to the coronavirus. SARS-CoV-2 can mimic the proteins of a human cell to evade detection by the immune system. Once inside the cell, it can […]
PNAS: Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection
August 3, 2020
Rebecca K Lane 1, Hongyan Guo 2, Amanda D Fisher 1, Jonathan Diep 3, Zhao Lai 4 5, Yidong Chen 5 6, Jason W Upton 7, Jan Carette 3, Edward S Mocarski 8, William J Kaiser 9 Abstract Herpesviruses are ubiquitous human pathogens that cause a wide range of health complications. Currently, there is an incomplete understanding of cellular factors that contribute to herpesvirus infection. Here, we report an antiviral necroptosis-based genetic screen to identify novel […]
Gupta Lab: COVID19 Press Clippings Archive
July 30, 2020