All News
Clinical Cancer Research: The B7-H3-targeting antibody-drug conjugate m276-SL-PBD is potently effective against pediatric cancer preclinical solid tumor models
February 15, 2021
Nathan M. Kendsersky, Jarrett M Lindsay, Edward A. Kolb, Malcolm A. Smith, Beverly A. Teicher, Stephen Erickson, Eric J Earley, Yaël P. Mossé, Daniel Martinez, Jennifer Pogoriler, Kateryna Krytska, Khushbu Patel, David Groff, Matthew Tsang, Samson Ghilu, Yifei Wang, Steven Seaman, Yang Feng, Brad St. Croix, Richard Gorlick, Raushan T. Kurmasheva, Peter J. Houghton and John M. Maris Abstract Purpose: Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by the CD276 gene that is overexpressed in many pediatric cancers. Here, we investigate the […]
Oncogene: MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma
February 9, 2021
Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark Edward Puhaindran, Peter Houghton, Angela Pang, Victor Kwanmin Lee, Ling-Wen Ding, Sigal Gery, Jeffrey Hill, Leilei Chen, Liang Xu & H. Phillip Koeffler Abstract Soft tissue sarcoma (STS) is a heterogeneous disease that arises from connective tissues. Clinical outcomes of patients […]
Cell Press: A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity (Zheng Lab)
January 21, 2021
Evan O.Paull114, Alvaro Aytes121314, Sunny J.Jones114, Prem S.Subramaniam1, Federico M.Giorgi3, Eugene F.Douglass1, Somnath Tagore1, Brennan Chu1, Alessandro Vasciaveo1, Siyuan Zheng4, Roel Verhaak5, Cory Abate-Shen1678, Mariano J.Alvarez19, Andrea Califano16910111215 Summary Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a network-based approach, identified 407 […]
Methods: Prediction and interpretation of cancer survival using graph convolution neural networks (Chen)
January 21, 2021
RicardoRamireza, Yu-ChiaoChiub, SongYaoZhangc, JoshuaRamireza, YidongChenbd, YufeiHuangad, Yu-FangJina Highlights • Predicting cancer survival outcomes using Graph Convolutional Neural Networks with TCGA dataset. • Combining clinical data and the GCNN improves cancer prognostic prediction. • Interpreting the GCNN model and identifying significant genes with network modules identified by HotNet2. Abstract The survival rate of cancer has increased […]
MDPI: Synergism of Proneurogenic miRNAs Provides a More Effective Strategy to Target Glioma Stem Cells (Penalva & Pertsemlidis Labs)
January 14, 2021
Adam Kosti, Rodrigo Barreiro, Gabriela D. A. Guardia, Shiva Ostadrahimi, Erzsebet Kokovay, Alexander Pertsemlidis, Pedro A. F. Galante, Luiz O. F. Penalva Simple Summary miRNAs function as critical regulators of gene expression and have been defined as contributors to cancer phenotypes by acting as oncogenes or tumor suppressors. Based on these findings, miRNA-based therapies have been explored in the treatment of many […]
BMC Microbiology: Comparison of rectal swab, glove tip, and participant-collected stool techniques for gut microbiome sampling
January 14, 2021
Meghan I. Short, Robert Hudson, Benjamin D. Besasie, Kelly R. Reveles, Dimpy P. Shah, Susannah Nicholson, Teresa L. Johnson-Pais, Korri Weldon, Zhao Lai, Robin J. Leach, Bernard Fongang & Michael A. Liss Abstract Background Studies of the gut microbiome are becoming increasingly important. Such studies require stool collections that can be processed or frozen in a […]
Nature Communications: Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation (Zheng Lab)
January 12, 2021
Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow & Siyuan Zheng Abstract Active telomerase is essential for stem cells and most cancers to maintain telomeres. The enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the catalytic subunit of the complex. Here we […]
Cancer Letters: COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice
January 9, 2021
Author links open overlay panelRosângela MayerGonçalvesa, MarinaDelgoboa, Jonathan PauloAgnesa, Raquel Nascimentodas Nevesa, MarceloFalchettia, TuanyCasagrandea, Ana Paula VargasGarciab, Thaynan CunhaVieirab, NauanaSomensic, Maciel AlencarBruxeld, Daniel Augusto Gasparin BuenoMendese, AlexRafachod, AndréBáficae, Daniel PensGelainc, José Cláudio FonsecaMoreirac, Geovanni DantasCassalib, Alexander James RoyBishopf, AlfeuZanotto-Filhoa Highlights • HSF diet accelerates mammary tumor formation in mice exposed to a carcinogen. • COX-2 […]
Postdoctoral Fellow Opening (Rao Lab)
January 1, 2021
The Greehey Children’s Cancer Research Institute (Greehey CCRI) at the UT Health Science Center – San Antonio is looking for an outstanding postdoctoral fellow to work in the laboratory of Dr. Manjeet Rao, PhD. We are seeking a self-motivated postdoctoral fellow to work on the role of epigenetic modifiers in tumor growth and metastasis. The […]
Yahoo Finance: Greehey CCRI Deputy Director, Manjeet Rao, PhD to Present at the 2021 San Antonio Breast Cancer Symposium (SABCS)
December 8, 2020
This year’s conference will feature an oral presentation by Manjeet Rao, PhD, about a possible FDA-approved anti-depressant being studied that may block breast cancer growth by preventing breast cancer cells from repairing themselves. Dr. Rao has been studying the unique ability of cancer cells to repair DNA damage caused by either unchecked growth or chemotherapy and […]