Research Paper
Nature Communications: Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma (Ignatius, Houghton, Chen)
January 14, 2021
Silvia Pomella, Prethish Sreenivas, Berkley E. Gryder, Long Wang, David Milewski, Matteo Cassandri, Kunal Baxi, Nicole R. Hensch, Elena Carcarino, Young Song, Hsien-Chao Chou, Marielle E. Yohe, Benjamin Z. Stanton, Bruno Amadio, Ignazio Caruana, Cristiano De Stefanis, Rita De Vito, Franco Locatelli, Yidong Chen, Eleanor Y. Chen, Peter Houghton, Javed Khan, Rossella Rota & Myron S. […]
Nature Communications: Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation (Zheng Lab)
January 12, 2021
Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow & Siyuan Zheng Abstract Active telomerase is essential for stem cells and most cancers to maintain telomeres. The enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the catalytic subunit of the complex. Here we […]
Cancer Letters: COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice
January 9, 2021
Author links open overlay panelRosângela MayerGonçalvesa, MarinaDelgoboa, Jonathan PauloAgnesa, Raquel Nascimentodas Nevesa, MarceloFalchettia, TuanyCasagrandea, Ana Paula VargasGarciab, Thaynan CunhaVieirab, NauanaSomensic, Maciel AlencarBruxeld, Daniel Augusto Gasparin BuenoMendese, AlexRafachod, AndréBáficae, Daniel PensGelainc, José Cláudio FonsecaMoreirac, Geovanni DantasCassalib, Alexander James RoyBishopf, AlfeuZanotto-Filhoa Highlights • HSF diet accelerates mammary tumor formation in mice exposed to a carcinogen. • COX-2 […]
Emily Selig of Libich Lab, Awarded a Spot on CPRIT Training Grant
January 8, 2021
Emily Selig recently earned her PhD at the University of Melbourne, Australia where she was employing biophysical and biochemical approaches to investigate the mechanisms by which the small heat-shock proteins aB-crystallin and heat-shock protein 27 (Hsp27) inhibit protein misfolding and incorporation into amyloid fibrils. These proteins are ubiquitously expressed chaperone proteins responsible […]
MDPI: MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation
December 5, 2020
Rebecca Pötschke 1,2,† Jacob Haase 1,†, Markus Glaß 1 Sebastian Simmermacher 3,Claudia Misiak 1,Luiz O. F. Penalva 4,5 Caspar D. Kühnöl, 2 and Stefan Hüttelmaier 1, Simple Summary Glioblastoma (GBM) is the most lethal brain tumor with a median survival rate of approximately 14 months. GBM patients commonly suffer from tumor recurrence, indicating that populations of chemo/radio-resistant stem cell-like tumor cells […]
Molecular Oncology: Interaction of transcription factor AP‐2 gamma with proto‐oncogene PELP1 promotes tumorigenesis by enhancing RET signaling
December 2, 2020
Junhao Liu, Zexuan Liu, Mengxing Li, , Weiwei Tang, Uday P. Pratap, Yiliao Luo, Kristin A. Altwegg, Xiaonan Li, Yi Zou, Hong Zhu, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi Abstract A significant proportion of estrogen receptor‐positive (ER+) breast cancer (BC) initially responds to endocrine therapy but eventually evolves into therapy‐resistant BC. Transcription factor AP‐2 gamma (TFAP2C) is a known regulator of ER […]
PNAS: Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility
November 24, 2020
Yuan Lu, View ORCID ProfileAngel Sandoval, View ORCID ProfileSarah Voss, Zhao Lai, Susanne Kneitz, Will Boswell, Mikki Boswell, Markita Savage, View ORCID ProfileChristi Walter, Wes Warren, View ORCID ProfileManfred Schartl, and Ronald Walter Abstract Mixing genomes of different species by hybridization can disrupt species-specific genetic interactions that were adapted and fixed within each species population. Such disruption can predispose the hybrids to abnormalities and disease that […]
Mucosal Immunology: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion
November 19, 2020
Wayne T. Muraoka, Anna A. Korchagina, Qingqing Xia, Sergey A. Shein, Xi Jing, Zhao Lai, Korri S. Weldon, Li-Ju Wang, Yidong Chen, Lawrence W. Kummer, Markus Mohrs, Eric Vivier, Ekaterina P. Koroleva & Alexei V. Tumanov Abstract Innate lymphoid cells (ILCs) are a heterogeneous family of immune regulators that protect against mucosal pathogens but can also […]
Nature Communications: Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells (Pertsemlidis)
November 16, 2020
Justin B. Moroney, Anusha Vasudev, Alexander Pertsemlidis, Hong Zan & Paolo Casali Abstract Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B cells (NBC), IgD+ unswitched (unsw)MBCs, and IgG+ or IgA+ class-switched (sw)MBCs from humans of different age, sex and race. Conserved antibody variable gene expression […]
Argonne National Laboratory: Hide and Seek: Understanding How COVID-19 Evades Detection in a Human Cell (Gupta)
November 3, 2020
BY ANDRE SALLES |OCTOBER 29, 2020 Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body. Scientists around the world have been working for months to identify and develop treatments that combat SARS-CoV-2, the virus that causes COVID-19. An important part of that process […]