Category
October 4, 2021
Amanda E. Lipsitt, Patricia K. DeForest, Andrea J. Canon, Andrea R. Gilbert, and Gail E. Tomlinson Introduction The following is a story in the form of a collection of personal perspectives from our medical team members who treated a young woman with osteosarcoma and worked together to realize her final wish. She not only made an [...]September 28, 2021
Roxane R. Lavoie Patricio C. Gargollo Mohamed E. Ahmed Yohan Kim Emily Baer Doris A. Phelps Cristine M. Charlesworth Benjamin J. Madden Liguo Wang Peter J. Houghton John Cheville Haidong Dong Candace F. Granberg Fabrice Lucien Simple Summary Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, and there is a critical need to […]
September 23, 2021
Authors: Lisa M Smith, Jason T. Ladner, Vida L. Hodara, Laura M. Parodi, R. Alan Harris, Jessica E. Callery, Zhao Lai, Yi Zou, Muthuswamy Raveedran, Jeffrey Rogers, and Luis D. Giavedoni Abstract Human and simian immunodeficiency virus infections establish a lifelong reservoir of cells harboring an integrated proviral genome. Genome editing CRISPR-associated Cas9 nucleases, combined […]
September 21, 2021
Amanda M. Gutierrez[Opens in a new windo Jill O. Robinson, Simon M. Outram, Hadley S. Smith, Stephanie A. Kraft, Katherine E. Donohue, Barbara B. Biesecker, Kyle B. Brothers, Flavia Chen, Benyam Hailu, Lucia A. Hindorff, Hannah Hoban, Rebecca L. Hsu, Sara J. Knight, Barbara A. Koenig, Katie L. Lewis, Kristen Hassmiller Lich, Julianne M. O’Daniel, […]
September 10, 2021
Neha S. Gandhi Edina Wang Anabel Sorolla Yu Jie Kan Adil Malik Jyotsna Batra Kimberly A. Young Wan Jun Tie Pilar Blancafort Ricardo L. Mancera Abstract SOX2 is an oncogenic transcription factor overexpressed in nearly half of the basal-like triple-negative breast cancers associated with very poor outcomes. Targeting and inhibiting SOX2 is clinically relevant as […]
September 9, 2021
Elvira C.van Dalena Renée L.Muldera EugeneSuhb Matthew J.Ehrhardtc Gregory J.Auned EditBardief Bradley J.Bensong JuttaBergler-Kleinh Ming H.Cheni EvaFreyf UlrikeHennewigj LianeLockwoodk UllaMartinssonl MonicaMuracam Helenavan der Pala ChrisPlummern KatrinScheinemannopq ChristinaSchinderars Daniel A.Mulrooneyc Highlights • Cancer survivors are at risk for premature coronary artery disease (CAD). • Especially survivors treated with radiotherapy exposing the heart. • This guideline provides […]
August 31, 2021
Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius Abstract Ionizing radiation (IR) and chemotherapy are mainstays of treatment for patients with rhabdomyosarcoma (RMS), yet the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor SNAI2 was previously identified as a key regulator of IR sensitivity in […]
August 30, 2021
Eric Alves1,2*,Emily McLeish3,Pilar Blancafort1,2,4,Jerome D. Coudert3,5,6†Silvana Gaudieri1,7,8† Abstract The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellular distress, damage, or transformation. Signaling through the NKG2D receptor-ligand axis is critical for early detection of viral infection or oncogenic transformation and the presence of functional […]
August 30, 2021
Raushan T. Kurmasheva, Stephen W. Erickson, Ruolan Han, Beverly A. Teicher, Malcolm A. Smith, Michael Roth, Richard Gorlick, Peter J. Houghton Abstract SP-2577(Seclidemstat), an inhibitor of lysine-specific demthylase KDM1A (LSD1) that is overexpressed in pediatric sarcomas, was evaluated against pediatric sarcoma xenografts. SP-2577 (100 mg/kg/day × 28 days) statistically significantly (p < .05) inhibited the growth of three of eight Ewing sarcoma (EwS), four […]
August 30, 2021
Antoine Baudin, Xiaoping Xu & David S. Libich Abstract SERBP1 is a multifunctional mRNA-binding protein that has been shown to play a regulatory role in a number of biological processes such as thrombosis, DNA damage repair, and the cellular response to nutrient deprivation. Additionally, SERBP1 is upregulated in glioblastoma, leukemia as well as liver, prostrate and […]