Research Paper
Aging Cell: Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury (Chen Lab)
June 12, 2021
Hak Joo Lee, Andrew Donati, Denis Feliers, Yuyang Sun, Yanli Ding, Muniswamy Madesh, Adam B. Salmon, Yuji Ikeno, Corinna Ross, Christopher L. O’Connor, Wenjun Ju, Markus Bitzer, Yidong Chen, Goutam Ghosh Choudhury, Brij B. Singh, Kumar Sharma, Balakuntalam S. Kasinath Abstract The mechanism of kidney injury in aging is not well understood. In order to […]
Molecular Cancer Therapeutics: International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer (Houghton)
June 4, 2021
Gilles Vassal, Peter J Houghton, Stefan M Pfister, Malcolm A. Smith, Huib N Caron, Xiao-Nan Li, David J Shields, Olaf Witt, Jan J Molenaar, Sara Colombetti, Julia Schuler, and Lou F Stancato Abstract Cancer remains the leading cause of disease-related death in children. For the many children who experience relapses of their malignant solid tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment elements that match the molecular make-up […]
Nature Communications: Metal ions help COVID-19 virus to disguise itself (Gupta Lab)
June 2, 2021
SAN ANTONIO (June 2, 2021) — Scientists from The University of Texas Health Science Center at San Antonio (Gupta Lab) and other collaborators have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions — positively charged atoms such as magnesium, manganese, […]
Leibert Pub: Zebrafish Tumor Graft Transplantation to Grow Tumors In Vivo That Engraft Poorly as Single Cell Suspensions (Ignatius Lab)
May 21, 2021
Amanda Lipsitt, Nicole R. Hensch, Rodrigo Moreno-Campos, Kunal Baxi, Jiangfei Chen, Anil K. Challa, Eleanor Y. Chen, and Myron S. Ignatius Abstract Angiosarcoma is a clinically aggressive tumor with a high rate of mortality. It can arise in vascular or lymphatic tissues, involve any part of the body, and aggressively spread locally or metastasize. Angiosarcomas spontaneously develop in the tp53 deleted (tp53del/del) zebrafish mutant. […]
NIH Grant Awarded to Collaborative Team to Eradicate Ewing Sarcoma (Aune)
May 13, 2021
Despite the breakthroughs being made in treating many cancers with less toxic, targeted, and immune-based therapies, Ewing sarcoma’s 40-year-old chemotherapy regimen remains a significant contributor to mortality and long-term cardiovascular complications adolescent and young adult cancer patients. An ongoing collaborative project initiated by the Rutledge Cancer Foundation collaborates with Qana Therapeutics, Greehey Children’s Cancer Research […]
BMC Bioinformatics: CancerSiamese: one-shot learning for predicting primary and metastatic tumor types unseen during model training (Chen Lab)
May 13, 2021
Milad Mostavi, Yu-Chiao Chiu, Yidong Chen & Yufei Huang Abstract Background The state-of-the-art deep learning-based cancer type prediction can only predict cancer types whose samples are available during the training where the sample size is commonly large. In this paper, we consider how to utilize the existing training samples to predict cancer types unseen during the […]
Journal of Clinical Medicine: Recent Developments in Nanomedicine for Pediatric Cancer (Kurmasheva)
April 30, 2021
by Shicheng Yang 1, Mia Wallach 2 , Apurva Krishna 3, Raushan Kurmasheva 4,5,*,† and Srinivas Sridhar 1,3,6,*,† Abstract Cancer is the second biggest cause of death in children in the US. With the development of chemotherapy, there has been a substantial increase in the overall survival rate in the last 30 years. However, the […]
International Journal of Molecular Sciences: A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes (Rao Lab)
April 30, 2021
Raushanara Akter 1, Afrina Afrose 1, Md Rashidur Rahman 2, Rakhi Chowdhury 1, Saif Shahriar Rahman Nirzhor 3, Rubayat Islam Khan 4, Md Tanvir Kabir 1 ABSTRACT Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by […]
JCM: Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children’s Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force (Houghton)
April 30, 2021
by Holly L. Pacenta 1,2, Wendy Allen-Rhoades, 3, David Langenau, 4, Peter J. Houghton, 5, Charles Keller 6, Christine M. Heske, 7 , Michael D. Deel, 8, Corinne M. Linardic, 8 , Jack F. Shern 7, Elizabeth Stewart, 9, Brian Turpin, 10, Douglas J. Harrison, 11, Javed Khan, 12, Leo Mascarenhas, 13,14 , Stephen X. […]
A review article by Dr. Raushan Kurmasheva (senior author) gives an overview on recent developments in nanomedicine for pediatric cancer
April 30, 2021
Recent Developments in Nanomedicine for Pediatric Cancer by Shicheng Yang 1, Mia Wallach 2OrcID, Apurva Krishna 3, Raushan Kurmasheva 4,5,*,†OrcID and Srinivas Sridhar 1,3,6,*,† Abstract Cancer is the second biggest cause of death in children in the US. With the development of chemotherapy, there has been a substantial increase in the overall survival rate in […]