NIH Grant Awarded to Collaborative Team to Eradicate Ewing Sarcoma (Aune)

May 13, 2021

Despite the breakthroughs being made in treating many cancers with less toxic, targeted, and immune-based therapies, Ewing sarcoma’s 40-year-old chemotherapy regimen remains a significant contributor to mortality and long-term cardiovascular complications adolescent and young adult cancer patients. An ongoing collaborative project initiated by the Rutledge Cancer Foundation collaborates with Qana Therapeutics, Greehey Children’s Cancer Research […]

BMC Bioinformatics: CancerSiamese: one-shot learning for predicting primary and metastatic tumor types unseen during model training (Chen Lab)

May 13, 2021

Milad Mostavi, Yu-Chiao Chiu, Yidong Chen & Yufei Huang Abstract Background The state-of-the-art deep learning-based cancer type prediction can only predict cancer types whose samples are available during the training where the sample size is commonly large. In this paper, we consider how to utilize the existing training samples to predict cancer types unseen during the […]

International Journal of Molecular Sciences: A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes (Rao Lab)

April 30, 2021

Raushanara Akter 1, Afrina Afrose 1, Md Rashidur Rahman 2, Rakhi Chowdhury 1, Saif Shahriar Rahman Nirzhor 3, Rubayat Islam Khan 4, Md Tanvir Kabir 1 ABSTRACT Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by […]

JCM: Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children’s Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force (Houghton)

April 30, 2021

by  Holly L. Pacenta 1,2, Wendy Allen-Rhoades,  3, David Langenau,  4, Peter J. Houghton,  5, Charles Keller 6, Christine M. Heske,  7 , Michael D. Deel,  8, Corinne M. Linardic,  8 , Jack F. Shern 7, Elizabeth Stewart,  9, Brian Turpin,  10, Douglas J. Harrison,  11, Javed Khan,  12, Leo Mascarenhas,  13,14 , Stephen X. […]

A review article by Dr. Raushan Kurmasheva (senior author) gives an overview on recent developments in nanomedicine for pediatric cancer

April 30, 2021

Recent Developments in Nanomedicine for Pediatric Cancer by Shicheng Yang 1, Mia Wallach 2OrcID, Apurva Krishna 3, Raushan Kurmasheva 4,5,*,†OrcID and Srinivas Sridhar 1,3,6,*,† Abstract Cancer is the second biggest cause of death in children in the US. With the development of chemotherapy, there has been a substantial increase in the overall survival rate in […]

Frontiers in Molecular Biosciences: The Role of Human Centromeric RNA in Chromosome StabilityThe Role of Human Centromeric RNA in Chromosome Stability (Kitagawa Lab)

April 20, 2021

 Introduction Accurate chromosome segregation is fundamental for cell division. Errors in this process can lead to chromosome instability, leading to aneuploidy, which is correlated with cancer (Zhu et al., 2011; Santaguida and Amon, 2015). The centromere is a component of each chromosome used for accurate chromosome segregation. The kinetochore, the structure responsible for binding the chromosome [...]

The Journal of Clinical Medicine Special Issue: The Current Treatment of Childhood Cancer”, for which Dr. Raushan Kurmasheva is Guest Editor

April 20, 2021

Special Issue Information Dear Colleagues, In the last four decades, the 5-year survival rate of children with cancer has increased from 58% to 83%, with the standard of care for these children relying on surgery, radiation therapy, and systemic therapy using cytotoxic agents. While cytotoxic therapies may induce complete responses in children with metastatic or […]

Cold Spring Harbor Molecular Case Studies: Bloom syndrome in a Mexican-American family with rhabdomyosarcoma: evidence of a Mexican founder mutation (Bishop, Chen, Tomlinson)

April 9, 2021

Erin H. Sybouts1,2,11, Adam D. Brown1,2,8,11, Maria G. Falcon-Cantrill3,9,11, Martha H. Thomas1,10, Thomas DeNapoli4,5, Julie Voeller5,6, Yidong Chen1,7, Gail E. Tomlinson1,3 and Alexander J.R. Bishop1,2 Abstract Bloom syndrome is a rare autosomal recessive disorder with less than 300 cases reported in the literature. Bloom syndrome is characterized by chromosome instability, physical stigmata, growth deficiency, immunodeficiency, and […]

MDPI: Samson Ghilu, Raushan Kurmasheva, and Peter Houghton publish a perspective on developing new agents for treatment of childhood cancer, and its challenges and opportunities for preclinical testing

April 4, 2021

Abstract Developing new therapeutics for the treatment of childhood cancer has challenges not usually associated with adult malignancies. Firstly, childhood cancer is rare, with approximately 12,500 new diagnoses annually in the U.S. in children 18 years or younger. With current multimodality treatments, the 5-year event-free survival exceeds 80%, and 70% of patients achieve long-term “cure”, […]