Frontiers in Molecular BioScience: Structural Characterization of the RNA-Binding Protein SERBP1 Reveals Intrinsic Disorder and Atypical RNA Binding Modes (Libich & Penalva labs)

October 13, 2021

 Antoine Baudin, 1 , 2 , † Alma K. Moreno-Romero, 1 , 2 Xiaoping Xu, 1 , 2 Emily E. Selig, 1 , 2 , † Luiz O. F. Penalva, 1 , 3 and David S. Libich 1 , 2 ,* † Abstract RNA binding proteins (RBPs) are essential for critical biological processes such as translation regulation and mRNA processing, and misfunctions of these proteins are associated with diseases such as cancer and neurodegeneration. SERBP1 (SERPINE1 [...]

Journal of Virology: MULTIPLEXED SIV-SPECIFIC PAIRED RNA-GUIDED CAS9 NICKASES INACTIVATE PROVIRAL DNA (Lai)

September 23, 2021

Authors: Lisa M Smith, Jason T. Ladner, Vida L. Hodara, Laura M. Parodi, R. Alan Harris, Jessica E. Callery, Zhao Lai, Yi Zou, Muthuswamy Raveedran, Jeffrey Rogers, and Luis D. Giavedoni Abstract Human and simian immunodeficiency virus infections establish a lifelong reservoir of cells harboring an integrated proviral genome. Genome editing CRISPR-associated Cas9 nucleases, combined […]

MDPI: Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor (Blancafort)

September 10, 2021

Neha S. Gandhi Edina Wang Anabel Sorolla Yu Jie Kan Adil Malik Jyotsna Batra Kimberly A. Young Wan Jun Tie Pilar Blancafort Ricardo L. Mancera Abstract SOX2 is an oncogenic transcription factor overexpressed in nearly half of the basal-like triple-negative breast cancers associated with very poor outcomes. Targeting and inhibiting SOX2 is clinically relevant as […]

European Journal of Cancer: Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group (Aune)

September 9, 2021

Elvira C.van Dalena Renée L.Muldera EugeneSuhb Matthew J.Ehrhardtc Gregory J.Auned EditBardief Bradley J.Bensong JuttaBergler-Kleinh Ming H.Cheni EvaFreyf UlrikeHennewigj LianeLockwoodk UllaMartinssonl  MonicaMuracam  Helenavan der Pala  ChrisPlummern  KatrinScheinemannopq  ChristinaSchinderars  Daniel A.Mulrooneyc Highlights • Cancer survivors are at risk for premature coronary artery disease (CAD). • Especially survivors treated with radiotherapy exposing the heart. • This guideline provides […]

Cancer Research: SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation (Houghton, Ignatius, & Zheng Labs)

August 31, 2021

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. Chen, Rossella Rota, Javed Khan, Peter J. Houghton and Myron S. Ignatius Abstract Ionizing radiation (IR) and chemotherapy are mainstays of treatment for patients with rhabdomyosarcoma (RMS), yet the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor SNAI2 was previously identified as a key regulator of IR sensitivity in […]

Frontiers in Immunolgy: Manipulating the NKG2D Receptor-Ligand Axis Using CRISPR: Novel Technologies for Improved Host Immunity (Blancafort)

August 30, 2021

Eric Alves1,2*,Emily McLeish3,Pilar Blancafort1,2,4,Jerome D. Coudert3,5,6†Silvana Gaudieri1,7,8† Abstract The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellular distress, damage, or transformation. Signaling through the NKG2D receptor-ligand axis is critical for early detection of viral infection or oncogenic transformation and the presence of functional […]

Pediatric Blood & Cancer: In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC) (Kurmasheva, Houghton)

August 30, 2021

Raushan T. Kurmasheva, Stephen W. Erickson, Ruolan Han, Beverly A. Teicher, Malcolm A. Smith, Michael Roth, Richard Gorlick, Peter J. Houghton Abstract SP-2577(Seclidemstat), an inhibitor of lysine-specific demthylase KDM1A (LSD1) that is overexpressed in pediatric sarcomas, was evaluated against pediatric sarcoma xenografts. SP-2577 (100 mg/kg/day × 28 days) statistically significantly (p < .05) inhibited the growth of three of eight Ewing sarcoma (EwS), four […]