Category
August 16, 2017
“Big Data” is a driving force in cancer research today. Sifting through the data from thousands of cancer genomes will help researchers understand what drives cancer, and help them make predictions about therapies that will be most beneficial to individual patients. To help make sense of these data, and in particular, to apply the findings […]
August 1, 2017
Maaged Akiel, Chunqing Guo, Xia Li, Devaraja Rajasekaran, Rachel G. Mendoza, Chadia L. Robertson, Nidhi Jariwala, Fang Yuan, Mark A. Subler, Jolene Windle, Dawn K. Garcia, Zhao Lai, Hung-I Harry Chen, Yidong Chen, Shah Giashuddin, Paul B. Fisher, Xiang-Yang Wang and Devanand Sarkar Abstract Activation of IGF signaling is a major oncogenic event in diverse cancers, including hepatocellular carcinoma (HCC). In this setting, the insulin-like growth factor-binding protein IGFBP7 inhibits IGF signaling by binding the IGF1 receptor (IGF1R), functioning as a candidate tumor suppressor. IGFBP7 abrogates tumors by inhibiting angiogenesis and […]
July 27, 2017
Peter Y. Yu , Heather L. Gardner , Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K. LeBlanc, Hui Xiao, Jiayuh Lin, Denis C. Guttridge, Xiaokui Mo, Chad E. Bennett, Christopher C. Coss, Yonghua Ling, Mitch A. Phelps, Peter Houghton, Cheryl A. London Abstract Background STAT3 is a transcription factor involved in cytokine and receptor kinase […]
July 15, 2017
Luke Jones 1, Jennifer Richmond 1, Kathryn Evans 1, Hernan Carol 1, Duohui Jing 1, Raushan T Kurmasheva 2, Catherine A Billups 3, Peter J Houghton 2, Malcolm A Smith 4, Richard B Lock 5 Abstract Purpose: Robust preclinical models of pediatric acute lymphoblastic leukemia (ALL) are essential in prioritizing promising therapies for clinical assessment in high-risk patients. Patient-derived xenograft (PDX) models of ALL provide a clinically relevant platform for assessing novel drugs, with […]
July 1, 2017
Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans and Sharon E. Plon Abstract Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in […]
July 1, 2017
Jennifer M Kalish 1, Leslie Doros 2, Lee J Helman 3, Raoul C Hennekam 4, Roland P Kuiper 5, Saskia M Maas 6, Eamonn R Maher 7, Kim E Nichols 8, Sharon E Plon 9, Christopher C Porter 10, Surya Rednam 9, Kris Ann P Schultz 11, Lisa J States 12, Gail E Tomlinson 13, Kristin Zelley 14, Todd E Druley 15 Abstract A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT), hepatoblastoma (HB), and other embryonal tumors. Here, we […]
July 1, 2017
Jonathan D Wasserman 1, Gail E Tomlinson 2, Harriet Druker 3, Junne Kamihara 4, Wendy K Kohlmann 5, Christian P Kratz 6, Katherine L Nathanson 7, Kristian W Pajtler 8 9, Andreu Parareda 10, Surya P Rednam 11, Lisa J States 12, Anita Villani 3, Michael F Walsh 13, Kristin Zelley 14, Joshua D Schiffman 15 Abstract Children and adolescents who present with neuroendocrine tumors are at extremely high likelihood of having an underlying germline predisposition for the multiple endocrine neoplasia (MEN) syndromes, including MEN1, […]
June 13, 2017
Myron S Ignatius 1, Madeline N Hayes 2, Riadh Lobbardi 2, Eleanor Y Chen 3, Karin M McCarthy 4, Prethish Sreenivas 5, Zainab Motala 6, Adam D Durbin 7, Aleksey Molodtsov 4, Sophia Reeder 4, Alexander Jin 4, Sivasish Sindiri 8, Brian C Beleyea 9, Deepak Bhere 10, Matthew S Alexander 11, Khalid Shah 9, Charles Keller 12, Corinne M Linardic 8, Petur G Nielsen 13, David Malkin 6, Javed Khan 8, David M Langenau 14 Abstract Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are […]
June 13, 2017
Jyoti Srivastava 1, Chadia L Robertson 1, Kareem Ebeid 2, Mikhail Dozmorov 3, Devaraja Rajasekaran 1, Rachel Mendoza 1, Ayesha Siddiq 1, Maaged A Akiel 1, Nidhi Jariwala 1, Xue-Ning Shen 1, Jolene J Windle 1, Mark A Subler 1, Nitai D Mukhopadhyay 3, Shah Giashuddin 4, Shobha Ghosh 5, Zhao Lai 6, Yidong Chen 7, Paul B Fisher 1 8 9, Aliasger K Salem 2 10, Arun J Sanyal 5, Devanand Sarkar 1 8 9 Abstract Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease in the Western world. However, an optimum therapy for NASH is yet […]
June 1, 2017
Erica Hlavin Bell 1, Stephanie L Pugh 2, Joseph P McElroy 3, Mark R Gilbert 4, Minesh Mehta 5, Alexander C Klimowicz 6, Anthony Magliocco 7, Markus Bredel 8, Pierre Robe 9, Anca-L Grosu 10, Roger Stupp 11, Walter Curran Jr 12, Aline P Becker 1, Andrea L Salavaggione 1, Jill S Barnholtz-Sloan 13, Kenneth Aldape 14, Deborah T Blumenthal 15, Paul D Brown 14, Jon Glass 16, Luis Souhami 17, R Jeffrey Lee 18, David Brachman 19, John Flickinger 20, Minhee Won 2, Arnab Chakravarti 1 Abstract Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in […]