European Urology: Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide

February 10, 2018

Emmanuel S.Antonarakisab†, ChangxueLub†  BrandonLubera  ChaoLiangb  HaoWanga  YanChenb  John L.Silbersteinb DaniloPianab ZhaoLaic YidongChencd William B.Isaacsab JunLuoab Abstract Background Inherited DNA-repair gene mutations are more prevalent in men with advanced prostate cancer than previously thought, but their clinical implications are not fully understood. Objective To investigate the clinical significance of germline DNA-repair gene alterations in men with metastatic castration-resistant prostate cancer (mCRPC) receiving next-generation hormonal […]

Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

February 7, 2018

Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which miR-195 represses the tumorigenesis of NSCLC cells are not fully understood. We performed a high-throughput […]

Childhood Obesity: Characterization of the Stool Microbiome in Hispanic Preschool Children by Weight Status and Time

February 1, 2018

Emily B Hollister 1 2, Byron A Foster 3, Mahmoud Dahdouli 1 2, Jesica Ramirez 4, Zhao Lai 5 Abstract Background: Variations in gut microbiota composition and diversity have been associated with childhood adiposity, although most studies describing this have been cross-sectional in nature. Our objective was to evaluate associations between body weight and the gut microbiota over time in obese preschool-age children. Methods: Obese, preschool-age, Hispanic children […]

Atlas of Science: The position of the centromere is marked with ubiquitylation of CENP-A

January 30, 2018

Chromosomes must segregate equally between daughter cells during cell division, and for proper chromosome segregation, spindle microtubules must attach to a single region of each chromosome, termed the “centromere,” in most eukaryotes. The kinetochore is a complex of proteins that is located at the centromere. Defects in this mechanism leads to chromosome instability (CIN). CIN, […]

Journal of Biological Chemistry: Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates

January 19, 2018

Preston Countryman 1, Yanlin Fan 2, Aparna Gorthi 3 4, Hai Pan 1, Jack Strickland 1, Parminder Kaur 1, Xuechun Wang 5, Jiangguo Lin 1 6, Xiaoying Lei 2 7, Christian White 1, Changjiang You 8, Nicolas Wirth 9, Ingrid Tessmer 9, Jacob Piehler 8, Robert Riehn 1, Alexander J R Bishop 3 4, Yizhi Jane Tao 2, Hong Wang 10 11 PMID: 29175904 PMCID: PMC5777247 DOI: 10.1074/jbc.M117.806406 Abstract Proper chromosome alignment and segregation during mitosis depend on the cohesion between sister chromatids, mediated by the cohesin protein complex, which also plays crucial roles in diverse genome […]

Neuro-Oncology: Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma

January 1, 2018

Shaofang Wu, Shuzhen Wang, Feng Gao, Luyuan Li, Siyuan Zheng, W K Alfred Yung, Dimpy Koul Abstract Background Oncogenic activation of phosphatidylinositol-3 kinase (PI3K) signaling plays a pivotal role in the development of glioblastoma (GBM). However, pharmacological inhibition of PI3K has so far not been therapeutically successful due to adaptive resistance through a rapid rewiring of cancer cell signaling. Here we […]

ACS Journals: Addressing late effects and quality of life essential to improving survivorship care (Aune Lab)

December 14, 2017

Abstract This news section offers Cancer readers timely information on events, public policy analysis, topical issues, and personalities. In this issue, we highlight efforts being made to improve cancer survivorship care and mitigate the late effects of cancer treatment. We also report on the increased risk for endocrine diseases among adolescent and young adult cancer survivors and […]

Genome Biology: The 3′ end of the story: deciphering combinatorial interactions that control mRNA fate.

November 29, 2017

Authors Penalva LOF Sanford JR Precise control of messenger RNA (mRNA) fate—its translation, stability, and localization—is required for accurate eukaryotic gene expression and is of fundamental importance to human health and disease. Initial efforts to determine how the cell controls these processes focused on “who done it?” We now understand that many of the clues […]

Pediatric Blood & Cancer: Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models

October 28, 2017

Abhik Bandyopadhyay 1, Edward Favours 1, Doris A Phelps 1, Vanessa Del Pozo 1, Samson Ghilu 1, Dias Kurmashev 1, Joel Michalek 2, Aron Trevino 2, Denis Guttridge 3, Cheryl London 4, Kenji Hirotani 5, Ling Zhang 5, Raushan T Kurmasheva 1, Peter J Houghton 1 Abstract Background: Integrating molecularly targeted agents with cytotoxic drugs used in the curative treatment of pediatric cancers is complex. An evaluation was undertaken with the ERBB3/Her3-specific antibody patritumab (P) either alone or with the ERBB1/epidermal growth factor […]

BMC Genomics: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer

October 3, 2017

Yu-Chiao Chiu, Li-Ju Wang, Tzu-Hung Hsiao, Eric Y. Chuang & Yidong Chen Abstract Background With the advances in high-throughput gene profiling technologies, a large volume of gene interaction maps has been constructed. A higher-level layer of gene-gene interaction, namely modulate gene interaction, is composed of gene pairs of which interaction strengths are modulated by (i.e., dependent on) the expression level […]