Research Paper
JCI Insight: Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL
April 17, 2016
Michelle L. Churchman,1 Kathryn Evans,2 Jennifer Richmond,2 Alissa Robbins,2 Luke Jones,2 Irina M. Shapiro,3 Jonathan A. Pachter,3 David T. Weaver,3 Peter J. Houghton,4 Malcolm A. Smith,5 Richard B. Lock,2 and Charles G. Mullighan1 Abstract BCR-ABL1+ B progenitor acute lymphoblastic leukemia (Ph+ B-ALL) is an aggressive disease that frequently responds poorly to currently available therapies. Alterations in IKZF1, which encodes the lymphoid transcription factor Ikaros, are present in over 80% of […]
Genes & Cancer: FGF19 functions as autocrine growth factor for hepatoblastoma
April 6, 2016
David J. Elzi1, Meihua Song1, Barron Blackman1, Susan T. Weintraub2, Dolores López-Terrada5, Yidong Chen1,3, Gail E. Tomlinson1,4 and Yuzuru Shiio1,2 ABSTRACT Hepatoblastoma is the most common liver cancer in children, accounting for over 65% of all childhood liver malignancies. Hepatoblastoma is distinct from adult liver cancer in that it is not associated with hepatitis virus infection, […]
RNA Biology: High-throughput analyses of hnRNP H1 dissects its multi-functional aspect
April 2, 2016
Authors Philip J Uren, Emad Bahrami-Samani, Patricia Rosa de Araujo, Christine Vogel, Mei Qiao, Suzanne C Burns, Andrew D Smith, Luiz OF Penalva hnRNPs are polyvalent RNA binding proteins that have been implicated in a range of regulatory roles including splicing, mRNA decay, translation, and miRNA metabolism. A variety of genome-wide studies have taken advantage […]
Journal of Community Support Oncology: Reaching high-risk underserved individuals for cancer genetic counseling by video-teleconferencing
April 1, 2016
Lindsey A Mette 1 2, Anna Maria Pulido Saldívar 2 3, Natalie E Poullard 1 2, Ivette C Torres 2 4, Sarah G Seth 1 2, Brad H Pollock 5 6, Gail E Tomlinson 7 2 6 Abstract Background: Breast and colorectal cancers are common cancers for which genetic risk assessment and counseling are available. However, these services are often limited to metropolitan areas and are not readily accessible to underserved populations. Moreover, ethnic and racial disparities […]
Experimental Biology and Medicine: Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease
March 27, 2016
Li Liu, Alexander Pertsemlidis, Liang-Hao Ding, Michael D Story, Martin H Steinberg, Paola Sebastiani, Carolyn Hoppe, Samir K Ballas, Betty S Pace Abstract Sickle cell disease (SCD) is a group of inherited blood disorders that have in common a mutation in the sixth codon of the β-globin (HBB) gene on chromosome 11. However, people with the same genetic mutation display a wide range […]
Pediatric Blood & Cancer: Initial Testing of NSC 750854, a Novel Purine Analog, Against Pediatric Tumor Models by the Pediatric Preclinical Testing Program
March 1, 2016
Richard Gorlick 1, E Anders Kolb 2, Stephen T Keir 3, John M Maris 4, Richard B Lock 5, Hernan Carol 5, C Patrick Reynolds 6, Min H Kang 6, Catherine A Billups 7, Jerry Collins 8, Dias Kurmashev 9, Raushan T Kurmasheva 9, Peter J Houghton 9, Malcolm A Smith 10 Abstract Background: NSC 750854 is a purine analog with an antitumor activity profile distinctive from that of other anticancer purines. It has shown significant activity against adult cancer preclinical models. Procedure: NSC […]
Scientific Report: Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-wide DNA Methylation Analysis
February 29, 2016
Yao Wang 1, Rohit Ramakant Jadhav 1, Joseph Liu 1, Desiree Wilson 2, Yidong Chen 3, Ian M Thompson 4 5, Dean A Troyer 6, Javier Hernandez 4, Huidong Shi 7, Robin J Leach 2 4 5, Tim H-M Huang 1 5, Victor X Jin 1 3 Abstract Aberrant DNA methylation at promoters is often linked to tumorigenesis. But many aspects of DNA methylation remain unexplored, including the individual roles of distal and gene body methylation, as well as their collaborative roles with […]
Pediatric Blood & Cancer: Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program
February 1, 2016
Edward F Attiyeh, John M Maris 1, Richard Lock 2, C Patrick Reynolds 3, Min H Kang 3, Hernan Carol 2, Richard Gorlick 4, E Anders Kolb 5, Stephen T Keir 6, Jianrong Wu 7, Yosef Landesman 8, Sharon Shacham 8, Dmitry Lyalin 9, Raushan T Kurmasheva 9, Peter J Houghton 9, Malcolm A Smith 10 Abstract Background: Selinexor (KPT-330) is an inhibitor of the major nuclear export receptor, exportin 1 (XPO1, also termed chromosome region maintenance 1, CRM1) that has demonstrated activity in preclinical models […]
IEEE: Cancer Progression Prediction Using Gene Interaction Regularized Elastic Net.
December 23, 2015
Lin Zhang; Hui Liu; Yufei Huang; Xuesong Wang; Yidong Chen; Jia Meng Abstract: Different types of genomic aberration may simultaneously contribute to tumorigenesis. To obtain a more accurate prognostic assessment to guide therapeutic regimen choice for cancer patients, the heterogeneous multi-omics data should be integrated harmoniously, which can often be difficult. For this purpose, we propose a Gene Interaction Regularized […]
Cure Today: The Circle of Life: Saving Fertility After Cancer
December 21, 2015
Cancer survivors have more options to save their fertility.