Category
September 1, 2017
Fabiana Marcelino Meliso, Christopher G Hubert, Pedro A Favoretto Galante, Luiz O Penalva Genomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes since our lack of effective therapies offers no tangible clinical starting point to build upon. The highly malignant […]
September 1, 2017
Authors Luiz O Penalva, Jeremy R Sanford Protein-coding genes defy the one gene-one enzyme paradigm, in part, through the process of alternative pre-mRNA splicing. This mode of gene regulation is critical for generating protein isoforms with specific functions in development and homeostasis (Kalsotra and Cooper 2011). Alternative pre-mRNA processing not only expands the protein-coding capacity […]
September 1, 2017
Trevi A. Mancilla (a1) and Gregory J. Aune (a1) Trevi A. Mancilla and Gregory J. Aune Abstract OBJECTIVES/SPECIFIC AIMS: Our research strives to understand the pathophysiology of doxorubicin cardiotoxicity, focusing on the understudied nonmyocyte cardiac cells. Our understanding will enable researchers to develop protective or alternative therapies for cancer patients and treatments for cancer survivors. METHODS/STUDY POPULATION: Early studies have […]
August 22, 2017
Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth & Lin Ji Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study, we identified a novel miR-SNP (rs713065) in the 3′UTR region of FZD4 gene linked with decreased risk of […]
August 17, 2017
Yohei Niikura,Risa Kitagawa,Hiroo Ogi &Katsumi Kitagawa ABSTRACT The centromere plays an essential role in accurate chromosome segregation, and defects in its function lead to aneuploidy and thus cancer. The centromere-specific histone H3 variant CENP-A is proposed to be the epigenetic mark of the centromere, as active centromeres require CENP-A–containing nucleosomes to direct the recruitment of multiple […]
August 16, 2017
“Big Data” is a driving force in cancer research today. Sifting through the data from thousands of cancer genomes will help researchers understand what drives cancer, and help them make predictions about therapies that will be most beneficial to individual patients. To help make sense of these data, and in particular, to apply the findings […]
August 1, 2017
Maaged Akiel, Chunqing Guo, Xia Li, Devaraja Rajasekaran, Rachel G. Mendoza, Chadia L. Robertson, Nidhi Jariwala, Fang Yuan, Mark A. Subler, Jolene Windle, Dawn K. Garcia, Zhao Lai, Hung-I Harry Chen, Yidong Chen, Shah Giashuddin, Paul B. Fisher, Xiang-Yang Wang and Devanand Sarkar Abstract Activation of IGF signaling is a major oncogenic event in diverse cancers, including hepatocellular carcinoma (HCC). In this setting, the insulin-like growth factor-binding protein IGFBP7 inhibits IGF signaling by binding the IGF1 receptor (IGF1R), functioning as a candidate tumor suppressor. IGFBP7 abrogates tumors by inhibiting angiogenesis and […]
July 27, 2017
Peter Y. Yu , Heather L. Gardner , Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K. LeBlanc, Hui Xiao, Jiayuh Lin, Denis C. Guttridge, Xiaokui Mo, Chad E. Bennett, Christopher C. Coss, Yonghua Ling, Mitch A. Phelps, Peter Houghton, Cheryl A. London Abstract Background STAT3 is a transcription factor involved in cytokine and receptor kinase […]
July 15, 2017
Luke Jones 1, Jennifer Richmond 1, Kathryn Evans 1, Hernan Carol 1, Duohui Jing 1, Raushan T Kurmasheva 2, Catherine A Billups 3, Peter J Houghton 2, Malcolm A Smith 4, Richard B Lock 5 Abstract Purpose: Robust preclinical models of pediatric acute lymphoblastic leukemia (ALL) are essential in prioritizing promising therapies for clinical assessment in high-risk patients. Patient-derived xenograft (PDX) models of ALL provide a clinically relevant platform for assessing novel drugs, with […]
July 1, 2017
Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans and Sharon E. Plon Abstract Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in […]