International Journal of Cancer: Integrin alpha 6 (ITGA6) is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex (Lai, Chen)

June 6, 2022

 Integrin alpha 6 (ITGA6) is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex Guixi Zheng,Hakim Bouamar,Matyas Cserhati,Carla R. Zeballos,Isha Mehta,Habil Zare,Larry Broome,Ruolei Hu,Zhao Lai,Yidong Chen,Francis E. Sharkey,Meenakshi Rani,Glenn A. Halff,Francisco G. Cigarroa,Lu-Zhe Sun Abstract Integrin α6 (ITGA6) forms integrin receptors with either integrin β1 (ITGB1) or integrin β4 (ITGB4). How it functions to [...]

Nature Communications: Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing (Sung)

April 27, 2022

 Chaoyou Xue, Sameer J. Salunkhe, Nozomi Tomimatsu, Ajinkya S. Kawale, Youngho Kwon, Sandeep Burma, Patrick Sung & Eric C. Greene Nature Communications volume 13, Article number: 2248 (2022) Cite this article Abstract Bloom syndrome (BS) is associated with a profoundly increased cancer risk and is caused by mutations in the Bloom helicase (BLM). BLM is involved in the nucleolytic processing of the [...]

Greehey CCRI to be at Southtown Siclovia, hosted by SATX YMCA

March 23, 2022

 Happy Wednesday, everyone! Riding in the Gear Up Against Kids Cancer on April 2nd but your bike isn't flying as it should? Then come see us at Siclovia this Sunday 3/27 10a-2P, with our good friends from Ride In Paradise Bicycle Shop Look for our HUGE ORANGE canopy in front of The Good Kind Cafe [...]

Patrick Sung, D. Phil, Appointed as Director of the Greehey Children’s Cancer Research Institute at UT Health San Antonio.

February 7, 2022

 Patrick Sung, DPhil, director of the Greehey Children’s Cancer Research Institute We are pleased to announce the appointment of Patrick Sung, D. Phil, as director of the Greehey Children’s Cancer Research Institute (GCCRI) at UT Health San Antonio, effective March 1, 2022. Dr. Sung currently serves as professor and interim chair of the Department of [...]

Biomolecular NMR Assignments: The 1H, 15N and 13C resonance assignments of the low-complexity domain from the oncogenic fusion protein EWS-FLI1 (Libich Lab)

January 12, 2022

 Courtney N. Johnson, Xiaoping Xu, Stephen P. Holloway & David S. Libich Abstract The RNA-binding protein EWS is a multifunctional protein with roles in the regulation of transcription and RNA splicing. It is one of the FET (FUS, EWS, and TAF15) family of RNA binding proteins that contain an intrinsically disordered, low-complexity N-terminal domain. The FET [...]

European Journal of Cancer: Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

December 6, 2021

 Elvira C.van Dalena Renée L.Muldera EugeneSuhb Matthew J.Ehrhardtc Gregory J.Auned Bradley J.Bensong JuttaBergler-Kleinh Ming H.Cheni EvaFreyf UlrikeHennewigj LianeLockwoodk UllaMartinssonl MonicaMuracam Helenavan der Pala ChrisPlummern KatrinScheinemannopq ChristinaSchinderars Daniel A.Mulrooneyc Highlights • Cancer survivors are at risk for premature coronary artery disease (CAD). • Especially survivors treated with radiotherapy exposing the heart. • This guideline provides recommendations [...]

Journal of Trauma & Acute Care Surgery: Whole Blood Resuscitation Restores Intestinal Perfusion and Influences Gut Microbiome Diversity (Lai)

August 24, 2021

Yracheta, Jaclyn MD1; Muraoka, Wayne PhD2; Wu, Xiaowu MD2; Burmeister, David PhD3; Darlington, Daniel PhD2; Zhao, David MD2; Lai, Zhao PhD4; Scroggins, Shannon MS1; Cap, Andrew P. MD, PhD2; Bynum, James PhD2; Nicholson, Susannah E. MD1,2 Abstract Objective Gut dysbiosis, an imbalance in the gut microbiome, occurs after trauma which may be ameliorated with transfusion. We […]

BMC Bioinformatics – Correlation AnalyzeR: Functional Predictions from Gene Co-Expression Correlations (Bishop Lab)

April 21, 2021

Henry E. Miller, Alexander J. R. Bishop Abstract Background Co-expression correlations provide the ability to predict gene functionality within specific biological contexts, such as different tissue and disease conditions. However, current gene co-expression databases generally do not consider the biological context. In addition, these tools often implement a limited range of unsophisticated analysis approaches, diminishing […]