Category
June 16, 2021
A childhood cancer survivor himself, Gregory J. Aune, MD, PhD, shares his personal experience and thoughts during National Cancer Survivor Month. (Originally posted on Medium on May 19th, Dr. Aune graciously agreed to share this with St. Baldrick’s.) Dr. Aune was a St. Baldrick’s Scholar 2014 – 2019, serves as […]
June 12, 2021
Hak Joo Lee, Andrew Donati, Denis Feliers, Yuyang Sun, Yanli Ding, Muniswamy Madesh, Adam B. Salmon, Yuji Ikeno, Corinna Ross, Christopher L. O’Connor, Wenjun Ju, Markus Bitzer, Yidong Chen, Goutam Ghosh Choudhury, Brij B. Singh, Kumar Sharma, Balakuntalam S. Kasinath Abstract The mechanism of kidney injury in aging is not well understood. In order to […]
June 4, 2021
Gilles Vassal, Peter J Houghton, Stefan M Pfister, Malcolm A. Smith, Huib N Caron, Xiao-Nan Li, David J Shields, Olaf Witt, Jan J Molenaar, Sara Colombetti, Julia Schuler, and Lou F Stancato Abstract Cancer remains the leading cause of disease-related death in children. For the many children who experience relapses of their malignant solid tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment elements that match the molecular make-up […]
June 2, 2021
SAN ANTONIO (June 2, 2021) — Scientists from The University of Texas Health Science Center at San Antonio (Gupta Lab) and other collaborators have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions — positively charged atoms such as magnesium, manganese, […]
May 21, 2021
Amanda Lipsitt, Nicole R. Hensch, Rodrigo Moreno-Campos, Kunal Baxi, Jiangfei Chen, Anil K. Challa, Eleanor Y. Chen, and Myron S. Ignatius Abstract Angiosarcoma is a clinically aggressive tumor with a high rate of mortality. It can arise in vascular or lymphatic tissues, involve any part of the body, and aggressively spread locally or metastasize. Angiosarcomas spontaneously develop in the tp53 deleted (tp53del/del) zebrafish mutant. […]
May 13, 2021
Despite the breakthroughs being made in treating many cancers with less toxic, targeted, and immune-based therapies, Ewing sarcoma’s 40-year-old chemotherapy regimen remains a significant contributor to mortality and long-term cardiovascular complications adolescent and young adult cancer patients. An ongoing collaborative project initiated by the Rutledge Cancer Foundation collaborates with Qana Therapeutics, Greehey Children’s Cancer Research […]
May 13, 2021
Milad Mostavi, Yu-Chiao Chiu, Yidong Chen & Yufei Huang Abstract Background The state-of-the-art deep learning-based cancer type prediction can only predict cancer types whose samples are available during the training where the sample size is commonly large. In this paper, we consider how to utilize the existing training samples to predict cancer types unseen during the […]
April 30, 2021
by Shicheng Yang 1, Mia Wallach 2 , Apurva Krishna 3, Raushan Kurmasheva 4,5,*,† and Srinivas Sridhar 1,3,6,*,† Abstract Cancer is the second biggest cause of death in children in the US. With the development of chemotherapy, there has been a substantial increase in the overall survival rate in the last 30 years. However, the […]
April 30, 2021
Raushanara Akter 1, Afrina Afrose 1, Md Rashidur Rahman 2, Rakhi Chowdhury 1, Saif Shahriar Rahman Nirzhor 3, Rubayat Islam Khan 4, Md Tanvir Kabir 1 ABSTRACT Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by […]
April 30, 2021
by Holly L. Pacenta 1,2, Wendy Allen-Rhoades, 3, David Langenau, 4, Peter J. Houghton, 5, Charles Keller 6, Christine M. Heske, 7 , Michael D. Deel, 8, Corinne M. Linardic, 8 , Jack F. Shern 7, Elizabeth Stewart, 9, Brian Turpin, 10, Douglas J. Harrison, 11, Javed Khan, 12, Leo Mascarenhas, 13,14 , Stephen X. [...]