Category
April 9, 2019
More and more people are living for years after treatment. Researchers should look for ways to identify and ease long-term effects. When Gregory Aune was 16, he wasn’t particularly concerned about the lasting effects of the drugs and radiation that he was given to treat his lymphoma. “I saw kids around me die, so I […]
April 9, 2019
Shahida K Flores, Ziming Cheng, Angela M Jasper, Keiko Natori, Takahiro Okamoto, Akiyo Tanabe, Koro Gotoh, Hirotaka Shibata, Akihiro Sakurai, Takuya Nakai, Xiaojing Wang, Magnus Zethoven, Shiva Balachander, Yuichi Aita, William Young, Jr., Siyuan Zheng, Kazuhiro Takekoshi, Eijiro Nakamura, Richard W Tothill, Ricardo C T Aguiar, Patricia L M Dahia Abstract Context von Hippel-Lindau (VHL) disease, comprising renal cancer, hemangioblastoma, and/or pheochromocytoma (PHEO), is caused by missense or truncating variants of the VHL tumor-suppressor gene, which […]
April 1, 2019
Susannah E Nicholson 1, David M Burmeister, Taylor R Johnson, Yi Zou, Zhao Lai, Shannon Scroggins, Mark DeRosa, Rachelle B Jonas, Daniel R Merrill, Caroline Zhu, Larry M Newton, Ronald M Stewart, Martin G Schwacha, Donald H Jenkins, Brian J Eastridge Abstract Background: Traumatic injury can lead to a compromised intestinal epithelial barrier and inflammation. While alterations in the gut microbiome of critically injured patients may influence clinical outcomes, the impact […]
March 29, 2019
Greehey CCRI Principal Investigator, Gregory J. Aune, MD, PhD, was quoted in a recent Science Magazine article regarding the long-term effects of childhood cancer treatments.
March 1, 2019
Michael A Liss 1 2, Robin J Leach 1 3, Elizabeth Rourke 1, Allison Sherrill 1, Teresa Johnson-Pais 1 3, Zhao Lai 4, Joseph Basler 1, James R White 5, Jan E Patterson 6 Abstract Purpose: Fluoroquinolone-resistant (FQR) Escherichia coli causes transrectal prostate biopsy infections. In order to reduce the colonization of these bacteria in carriers, we would like to understand the surrounding microbiome to determine targets for decolonization. Materials and methods: We perform an observational study to […]
March 1, 2019
Bo Wen, Xiaojing Wang, Bing Zhang Massively parallel or second-generation sequencing-based genomic studies continuously identify new genomic alterations that may lead to novel protein sequences, which are attractive candidates for disease biomarkers and therapeutic targets after proteomic validation. Integrative proteogenomic methods have been developed to use mass spectrometry (MS)-based proteomics data for such validation. These […]
February 28, 2019
Trevi R Mancilla, and Gregory J Aune Abstract The oldest cohort of childhood cancer survivors is entering into their sixth decade. The milestone comes with the knowledge that this population is at 15 times greater risk of cardiovascular events than the general population. One factor in this is doxorubicin, a chemotherapeutic drug commonly used to treat […]
February 26, 2019
Siyuan Zheng, PhD, assistant professor in the Department of Epidemiology and Biostatistics in the Long School of Medicine, has received a Rising STARs Award from the UT System. The award for early-career investigators comes with a $250,000 grant.
February 26, 2019
Samuel A. Kotler, Vitali Tugarinov, Thomas Schmidt, Alberto Ceccon, David S. Libich, Rodolfo Ghirlando, Charles D. Schwieters, and G. Marius Clore Abstract The N-terminal region of the huntingtin protein, encoded by exon-1, comprises an amphiphilic domain (httNT), a polyglutamine (Q n ) tract, and a proline-rich sequence. Polyglutamine expansion results in an aggregation-prone protein responsible for Huntington’s disease. Here, we study the earliest events […]
February 22, 2019
The Cancer Prevention and Research Institute of Texas has awarded 54 new academic research, prevention and product development grants totaling nearly $96 million. San Antonio’s cut is $3 million. All three Alamo City grants will support research at UT Health San Antonio. They include a pair of $900,000 awards and one for $1.2 million. Dr. Yuzuru […]