SHOCK: Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner

August 1, 2019

Nicholson, Susannah E.∗; Watts, Lora T.†; Burmeister, David M.‡; Merrill, Daniel∗; Scroggins, Shannon∗; Zou, Yi§; Lai, Zhao§; Grandhi, Ramesh∗; Lewis, Aaron M.∗; Newton, Larry M.∗; Eastridge, Brian J.∗; Schwacha, Martin G.∗,‡ Abstract The microbiome is defined as the collective genomes of the microbes (composed of bacteria, bacteriophage, fungi, protozoa, and viruses) that colonize the human body, and […]

Hepatology Communications: Posttranscriptional Inhibition of Protein Tyrosine Phosphatase Nonreceptor Type 23 by Staphylococcal Nuclease and Tudor Domain Containing 1: Implications for Hepatocellular Carcinoma

July 15, 2019

Nidhi Jariwala, Rachel G. Mendoza, Dawn Garcia, Zhao Lai, Mark A. Subler, Jolene J. Windle, Nitai D. Mukhopadhyay, Paul B. Fisher, Yidong Chen, Devanand Sarkar Abstract Oncoprotein staphylococcal nuclease and tudor domain containing 1 (SND1) regulates gene expression at a posttranscriptional level in multiple cancers, including hepatocellular carcinoma (HCC). Staphylococcal nuclease (SN) domains of SND1 function as a ribonuclease (RNase) and the tudor domain […]

Dr. Zhao Lai $600,000 NIH Shared Instrument grant

June 25, 2019

In March 2016, Dr. Zhao Lai was awarded $600,000 NIH Shared Instrument grant (S10 grant 1S10OD021805-01) to purchase Illumina HiSeq 3000 to upgrade the sequencing platform in GSF. Illumina HiSeq 3000/4000(3000 carries one flow cell vs HiSeq 4000 with two flow cell stations) is the latest and most efficient sequencing platform in Illumina NGS market. […]

Pediatric Blood & Cancer: Insights into pediatric rhabdomyosarcoma research: Challenges and goals

June 21, 2019

Marielle E Yohe 1, Christine M Heske 1, Elizabeth Stewart 2, Peter C Adamson 3, Nabil Ahmed 4, Cristina R Antonescu 5, Eleanor Chen 6, Natalie Collins 7, Alan Ehrlich 8, Rene L Galindo 9, Berkley E Gryder 1, Heidi Hahn 10, Sharon Hammond 11, Mark E Hatley 2, Douglas S Hawkins 12, Madeline N Hayes 13, Andrea Hayes-Jordan 14, Lee J Helman 15, Simone Hettmer 16, Myron S Ignatius 17, Charles Keller 18, Javed Khan 1, David G Kirsch 19, Corinne M Linardic 19, Philip J Lupo 4, Rossella Rota 20, Jack F Shern 1, Janet Shipley 21, Sivasish Sindiri 1, Stephen J Tapscott 22, Christopher R Vakoc 23, Leonard H Wexler 5, David M Langenau 13 Abstract Overall […]

Comprehensive Physiology Doxorubicin‐Induced Cardiomyopathy in Children

June 12, 2019

Trevi R. Mancilla, Brian Iskra, Gregory J. Aune ABSTRACT Doxorubicin‐induced cardiotoxicity in childhood cancer survivors is a growing problem. The population of patients at risk for cardiovascular disease is steadily increasing, as five‐year survival rates for all types of childhood cancers continue to improve. Doxorubicin affects the developing heart differently from the adult heart and in a […]

Clinical Cancer Research: A Phase II Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children’s Oncology Group Phase I and Pilot Consortium (ADVL0921)

June 1, 2019

Yael P Mossé 1 2, Elizabeth Fox 3 2, David T Teachey 3 2, Joel M Reid 4, Stephanie L Safgren 4, Hernan Carol 5, Richard B Lock 5, Peter J Houghton 6, Malcolm A Smith 7, David Hall 8, Donald A Barkauskas 8, Mark Krailo 9, Stephan D Voss 10, Stacey L Berg 11, Susan M Blaney 11, Brenda J Weigel 10 Abstract Purpose: Aurora A kinase (AAK) plays an integral role in the mitotic entry, DNA damage checkpoint recovery, and centrosome and spindle maturation. Alisertib (MLN8237) is a […]

Bioorganic & Medicinal Chemistry: Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types

June 1, 2019

JorgeDe La Chapaa, Matthew Valdezb, Franscisco RuizIIIb, Keith Gonzalesb, Wes Mitchellb, Stanton F.McHardybc, Matthew Hartbc, Srikanth R.Polusanib, Cara B.Gonzalesac Abstract We previously demonstrated that capsazepine (CPZ), a synthetic transient receptor potential Vanilloid subtype 1 (TRPV1) antagonist, has significant anti-cancer effects in vivo. The purpose of this study was to develop more potent analogs based upon CPZ pharmacophore and structure-activity relationships (SAR) across analogs. We […]

Journal of Translational Immunology: IL‐1 receptor antagonist, anakinra, prevents myocardial dysfunction in a mouse model of Kawasaki disease vasculitis and myocarditis

May 17, 2019

M. Gorelik  Y. Lee  M. Abe  T. Andrews L. Davis J. Patterson S. Chen T. R. Crother G. J. Aune M. Noval Rivas M. Arditi Summary Kawasaki disease (KD) vasculitis is an acute febrile illness of childhood characterized by systemic vasculitis of unknown origin and is the most common cause of acquired heart disease among children in the United States. While histological […]

Journal of Immunology: Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer

May 15, 2019

Merit L Goodman 1 2 3, Gloria M Trinca 1 2 3, Katherine R Walter 1 2 3, Evangelia K Papachristou 4, Clive S D’Santos 4, Tianbao Li 5, Qi Liu 5, Zhao Lai 5 6, Prabhakar Chalise 7, Rashna Madan 8, Fang Fan 8, Mary A Markiewicz 9, Victor X Jin 5, Jason S Carroll 4, Christy R Hagan 10 2 3 Abstract Why some tumors remain indolent and others progress to clinical relevance remains a major unanswered question in cancer biology. IFN signaling in nascent tumors, mediated by STAT1, is a […]