Cell Report: The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma

June 13, 2017

Myron S Ignatius 1, Madeline N Hayes 2, Riadh Lobbardi 2, Eleanor Y Chen 3, Karin M McCarthy 4, Prethish Sreenivas 5, Zainab Motala 6, Adam D Durbin 7, Aleksey Molodtsov 4, Sophia Reeder 4, Alexander Jin 4, Sivasish Sindiri 8, Brian C Beleyea 9, Deepak Bhere 10, Matthew S Alexander 11, Khalid Shah 9, Charles Keller 12, Corinne M Linardic 8, Petur G Nielsen 13, David Malkin 6, Javed Khan 8, David M Langenau 14 Abstract Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are […]

Hepatology: A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH)

June 13, 2017

Jyoti Srivastava 1, Chadia L Robertson 1, Kareem Ebeid 2, Mikhail Dozmorov 3, Devaraja Rajasekaran 1, Rachel Mendoza 1, Ayesha Siddiq 1, Maaged A Akiel 1, Nidhi Jariwala 1, Xue-Ning Shen 1, Jolene J Windle 1, Mark A Subler 1, Nitai D Mukhopadhyay 3, Shah Giashuddin 4, Shobha Ghosh 5, Zhao Lai 6, Yidong Chen 7, Paul B Fisher 1 8 9, Aliasger K Salem 2 10, Arun J Sanyal 5, Devanand Sarkar 1 8 9 Abstract Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease in the Western world. However, an optimum therapy for NASH is yet […]

JAMA Oncology: Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525

June 1, 2017

Erica Hlavin Bell 1, Stephanie L Pugh 2, Joseph P McElroy 3, Mark R Gilbert 4, Minesh Mehta 5, Alexander C Klimowicz 6, Anthony Magliocco 7, Markus Bredel 8, Pierre Robe 9, Anca-L Grosu 10, Roger Stupp 11, Walter Curran Jr 12, Aline P Becker 1, Andrea L Salavaggione 1, Jill S Barnholtz-Sloan 13, Kenneth Aldape 14, Deborah T Blumenthal 15, Paul D Brown 14, Jon Glass 16, Luis Souhami 17, R Jeffrey Lee 18, David Brachman 19, John Flickinger 20, Minhee Won 2, Arnab Chakravarti 1 Abstract Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in […]

Aging Cell: Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health

May 29, 2017

Ning Zhang 1, Joseph M Valentine 1, You Zhou 1, Mengyao E Li 1 2, Yiqiang Zhang 1, Arunabh Bhattacharya 1, Michael E Walsh 1, Katherine E Fischer 1, Steven N Austad 1, Pawel Osmulski 1, Maria Gaczynska 1, Steven E Shoelson 2, Holly Van Remmen 1, Hung I Chen 3 4, Yidong Chen 3 4, Hanyu Liang 1, Nicolas Musi 1 5 Abstract Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in […]

Nature: The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution

May 22, 2017

Hélène Badouin, Jérôme Gouzy, Christopher J. Grassa, Florent Murat, S. Evan Staton, Ludovic Cottret, Christine Lelandais-Brière, Gregory L. Owens, Sébastien Carrère, Baptiste Mayjonade, Ludovic Legrand, Navdeep Gill, Nolan C. Kane, John E. Bowers, Sariel Hubner, Arnaud Bellec, Aurélie érard, Hélène Bergès, Nicolas Blanchet, Marie-Claude Boniface, Dominique Brunel, Olivier Catrice, Nadia Chaidir, Clotilde Claudel, Cécile Donnadieu, Thomas Faraut, Ghislain Fievet, Nicolas Helmstetter, Matthew King, Steven J. Knapp, Zhao Lai, Marie-Christine Le Paslier, Yannick Lippi, Lolita Lorenzon, Jennifer R. Mandel, Gwenola Marage, Gwenaëlle Marchand, Elodie Marquand, Emmanuelle Bret-Mestries, Evan Morien, Savithri Nambeesan, Thuy Nguyen, Prune Pegot-Espagnet, Nicolas Pouilly, Frances Raftis, Erika Sallet, Thomas […]

PLOS One: Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma

May 4, 2017

Patricia C. Sanchez-Diaz ,Judy C. Chang ,Emily S. Moses,Tu Dao,Yidong Chen,Jaclyn Y. Hung  Abstract Pediatric high-grade gliomas represent 8–12% of all primary tumors of the nervous system in children. Five-year survival for these pediatric aggressive tumors is poor (15–35%) indicating the need to develop better treatments for pediatric high-grade gliomas. In this work we used SF188 and […]

InderScience: Computational tools for genome-wide R-loops identification and characterization

April 15, 2017

Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in various organisms and shown to play important roles in regulating gene expression, DNA replication, genome stability, and other functions. The recent introduction of the protocol of DNA-RNA Immune-Precipitation (DRIP) followed by […]

International Journal of Computational Biology and Drug Design: Computational tools for genome-wide R-loops identification and characterisation

April 15, 2017

Authors: Rongjie Liu; Aparna Gorthi; Yufang Jin; Alexander J.R. Bishop; Yidong Chen Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in various organisms and shown to play important roles in regulating gene expression, DNA replication, genome stability, and other functions. […]

PloS One: De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development

April 4, 2017

Patricia C Sanchez-Diaz 1, Tzu-Hung Hsiao, Judy C Chang, Dong Yue, Mimi C Tan, Hung-I Harry Chen, Gail E Tomlinson, Yufei Huang, Yidong Chen, Jaclyn Y Hung Abstract Background: microRNAs (miRNAs) have been implicated in the control of many biological processes and their deregulation has been associated with many cancers. In recent years, the cancer stem cell (CSC) concept has been applied to many cancers including […]

Axios: More people are surviving a cancer diagnosis

April 2, 2017

Survival rates for cancer patients in the U.S. continue to improve for many common types of the disease, according to a new report from top government agencies. Pancreatic, liver, brain, lung, and other cancers still have low rates of survival but prostate, melanoma, and breast cancers topped 90 percent in the period studied. The researchers also […]