Pediatric Blood & Cancer: In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC) (Kurmasheva, Houghton)

August 30, 2021

Raushan T. Kurmasheva, Stephen W. Erickson, Ruolan Han, Beverly A. Teicher, Malcolm A. Smith, Michael Roth, Richard Gorlick, Peter J. Houghton Abstract SP-2577(Seclidemstat), an inhibitor of lysine-specific demthylase KDM1A (LSD1) that is overexpressed in pediatric sarcomas, was evaluated against pediatric sarcoma xenografts. SP-2577 (100 mg/kg/day × 28 days) statistically significantly (p < .05) inhibited the growth of three of eight Ewing sarcoma (EwS), four […]

Biomolecular NMR Assignments: The 1H, 15N and 13C resonance assignments of the C‑terminal domain of Serpine mRNA binding protein 1 (SERBP1), (Libich Lab)

August 30, 2021

Antoine Baudin, Xiaoping Xu & David S. Libich Abstract SERBP1 is a multifunctional mRNA-binding protein that has been shown to play a regulatory role in a number of biological processes such as thrombosis, DNA damage repair, and the cellular response to nutrient deprivation. Additionally, SERBP1 is upregulated in glioblastoma, leukemia as well as liver, prostrate and […]

Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)

August 24, 2021

Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function screens have revealed genes essential for cancer cell proliferation, called cancer dependencies. It remains challenging to link cancer dependencies to the molecular compositions of cancer […]

BRCA2 Promotes Spontaneous Homologous Recombination In Vivo (Bishop)

August 9, 2021

Adam D. Brown, Scott Greenman, Alison B. Claybon, Alexander J. R. Bishop Simple Summary Inherited mutation of either BRCA1 or BRCA2 is associated with familial breast and ovarian cancer. As a tumor suppressor, BRCA2 functions to maintain genome stability but we do not know the genomic impact of this deficiency on normal tissues in normal contexts, rather than […]

Neuro-Oncololgy Advances: The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma (Houghton)

August 4, 2021

Craig Horbinski, Guifa Xi, Yufen Wang, Rintaro Hashizume, Mahesh Gopalakrishnan, Joanna J Phillips, Peter Houghton, Charles D James, John A Kalapurakal Abstract Background Meningiomas are the most common tumor arising within the cranium of adults. Despite surgical resection and radiotherapy, many meningiomas invade the brain, and many recur, often repeatedly. To date, no chemotherapy has proven effective against such tumors. Thus, there is […]

MSystems: Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia (Lai Lab)

August 4, 2021

Wurihan Wurihan , Yi Zou, Alec M. Weber, Korri Weldon, Yehong Huang, Xiaofeng Bao, Chengsheng Zhu, Xiang Wu, Yaqun Wang, Zhao Lai, and Huizhou Fan  ABSTRACT Chlamydia trachomatis is an obligate intracellular bacterium whose unique developmental cycle consists of an infectious elementary body and a replicative reticulate body. Progression of this developmental cycle requires temporal control of the transcriptome. In addition to the three chlamydial sigma factors (σ66, σ28, and σ54) that recognize promoter sequences of […]

Yogesh Gupta Awarded, 5-year $3.0 million R01 NIH/NIAID Grant to Support His SARS-CoV-2 and RNA Methylation Work.

July 29, 2021

Dr. Yogesh Gupta was awarded a 5-year $3.0 million R01 NIH/NIAID (National Institute of Allergy and Infectious Diseases) grant to support his SARS-CoV-2 and RNA methylation work. ABSTRACT The massive global pandemic with high morbidity and mortality makes Severe Acute Respiratory Syndrome coronavirus-2  (SARS-CoV-2) one of the deadliest viruses in recent history. It is especially noteworthy for hijacking the normal operations of […]

Science Advances: Regulation of telomere homeostasis and genomic stability in cancer by N6-adenosine methylation (m6A) (Rao & Zheng Labs)

July 29, 2021

View ORCID ProfileJi Hoon Lee1,†, View ORCID ProfileJuyeong Hong1,†, View ORCID ProfileZhao Zhang1,†, View ORCID ProfileBárbara de la Peña Avalos2,3, View ORCID ProfileCecilia J. Proietti4, View ORCID ProfileAgustina Roldán Deamicis4, View ORCID ProfilePablo Guzmán G.5, Hung-Ming Lam6, Jose Garcia6, Martine P. Roudier6, View ORCID ProfileAnthony E. Sisk7, View ORCID ProfileRichard De La Rosa1, View ORCID ProfileKevin Vu8, Mei Yang1, Yiji Liao1, View ORCID ProfileJessica Scheirer1, View ORCID ProfileDouglas Pechacek1, Pooja Yadav9,10, View ORCID […]

Scientific Reports: A comprehensive meta-analysis and a case–control study give insights into genetic susceptibility of lung cancer and subgroups (Bishop Lab)

July 19, 2021

Debmalya Sengupta, Souradeep Banerjee, Pramiti Mukhopadhyay (Bishop Lab)  Ritabrata Mitra, Tamohan Chaudhuri, Abhijit Sarkar, Gautam Bhattacharjee, Somsubhra Nath, Susanta Roychoudhury, Samsiddhi Bhattacharjee & Mainak Sengupta Abstract Reports of genetic association of polymorphisms with lung cancer in the Indian subcontinent are often conflicting. To summarise and replicate published evidence for association with lung cancer and its subgroups. […]