BioSpace: Hyundai Hope On Wheels Presents UT Health San Antonio With Hyundai Young Investigator And Scholar Hope Grant Totaling A Combined $500,000 To Support Pediatric Cancer Research (Aune & Ignatius Labs)

September 23, 2019

Hyundai Hope On Wheels® (HHOW), a 501(c)(3) non-profit organization supported by Hyundai and its U.S. dealers, announces $500,000 Hyundai Young Investigator and Scholar Hope Grant to UT Health San Antonio to continue its long-standing fight against pediatric cancer. HHOW has committed $13.2 million to support 52 new doctor-researchers in their research for better treatment options and to improve care for children diagnosed […]

Developmental Cell: CENP-A Ubiquitylation Is Indispensable to Cell Viability

September 23, 2019

Summary CENP-A is a centromere-specific histone H3 variant that epigenetically determines centromere identity, but how CENP-A is deposited at the centromere remains obscure. We previously reported that CENP-A K124 ubiquitylation, mediated by the CUL4A-RBX1-COPS8 complex, is essential for CENP-A deposition at the centromere. However, a recent report stated that CENP-A K124R mutants show no defects […]

September is Women in Medicine Month

September 19, 2019

  As part of the American Medical Association (AMA) “Women in Medicine Month”, we at the Greehey Children’s Cancer Research Institute – UT Health San Antonio would like to take a moment and celebrate the female faculty who have dedicated their careers to childhood cancer.     Christine Aguilar, MD, MPH, Faculty Associate, Greehey Children’s […]

KENS5: UT Health gets a $306,000 grant to study Ewing sarcoma

September 16, 2019

SAN ANTONIO — September is Childhood Cancer Awareness Month. One of those cancers, Ewing sarcoma, is the second most common type of bone cancer in children with only 200 diagnosed each year in the U.S. Thanks to a $306,000 grant from The St. Baldrick’s Foundation, UT Health San Antonio is working to find a cure […]

PLOS Biology: Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption

September 12, 2019

Jun Liu , Ming Gao , Michael Nipper, Janice Deng, Francis E. Sharkey, Randy L. Johnson, Howard C. Crawford, Yidong Chen, Pei Wang  Abstract Damaged acinar cells play a passive role in activating pancreatic stellate cells (PSCs) via the recruitment of immune cells that subsequently activate PSCs. However, whether acinar cells directly contribute to PSC activation is […]

The Journal of Clinical Endocrinology & Metabolism: Synonymous but Not Silent: A Synonymous VHL Variant in Exon 2 Confers Susceptibility to Familial Pheochromocytoma and von Hippel-Lindau Disease

September 1, 2019

Shahida K Flores, Ziming Cheng, Angela M Jasper, Keiko Natori, Takahiro Okamoto, Akiyo Tanabe, Koro Gotoh, Hirotaka Shibata, Akihiro Sakurai, Takuya Nakai, Xiaojing Wang, Magnus Zethoven, Shiva Balachander, Yuichi Aita, William Young, Jr., Siyuan Zheng, Kazuhiro Takekoshi, Eijiro Nakamura, Richard W Tothill, Ricardo C T Aguiar, Patricia L M Dahia Abstract Context von Hippel-Lindau (VHL) disease, comprising renal cancer, hemangioblastoma, and/or pheochromocytoma (PHEO), is caused by missense or truncating variants of the VHL tumor-suppressor gene, which […]